Covalent attachment of nucleic acid molecules onto solid-phases

Details Covalent attachment of nucleic acid molecules onto solid-phases Covalent attachment of nucleic acid molecules onto solid-phases

1997-03-05

1998-11-17

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 436501, 935 77, 935 78, C07H 2104, C07H 2100

Patent

active

058378600

ABSTRACT:
Methods for the covalent, specific and reversible immobilization of nucleic acid molecules onto solid-phases by means of a reversible disulfide bond for nucleic acid molecule array preparation are described. These methods can be used to prepare reusable nucleic acid molecule arrays with high specificity and high efficiency.

REFERENCES:
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Running, J.A. et al., BioTechniques 8:276-277 (1990).
Sliwkowski, M.X. et al., Biochem. J. 209: 731-739 (1983).

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