Covalent attachment of macromolecules to polysulfones or polyeth

Details Covalent attachment of macromolecules to polysulfones or polyeth Covalent attachment of macromolecules to polysulfones or polyeth

1994-02-02

1995-10-31

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435180, 436531, 436532, 436824, 530413, 530815, 530816, 568 28, C12N 1106, G01N 33549, C07K 1706, C07C31500

Patent

active

054628679

ABSTRACT:
A hydrophobic polymer such as polysulfone or polyethersulfone is modified to contain an increased number of functionalizable chain ends such as by treating with an alkali hydroxide to provide hydroxyl groups. A linker is covalently bonded to a chain end of the polymer and a macromolecule is covalently bonded to the linker. A ligand may be covalently bonded to the macromolecule. The macromolecule can be a natural polymer, a synthetic polymer or a biologically active species. The hydrophobic polymer is preferably in the form of a microporous membrane. By the use of a four-component dope composition, substantially isotropic microporous structures in the form of flat sheets or hollow fibers are produced. An improved spinnerette assembly is provided for the production of hollow fibers.

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