Covalent attachment of macromolecules on substrate surfaces

Details Covalent attachment of macromolecules on substrate surfaces Covalent attachment of macromolecules on substrate surfaces

1989-03-29

1990-06-12

Lipman, Bernard

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525374, C08F 830

Patent

active

049334107

ABSTRACT:
Uncrosslinked polystyrene surfaces are derivatized under Friedel-Crafts conditions in a tetramethylenesulfone solvent using a substituted N-hydroymethyl acetamide derivatizing agent. The substitutent is subject to nucleophilic substitution to allow for the binding of a wide variety of molecules, particularly specific binding pair members, to the surface. Clarity is maintained for monitoring observation of events on the surface through the polystyrene.

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