Covalent attachment of anticoagulants and the like onto biomater

Details Covalent attachment of anticoagulants and the like onto biomater Covalent attachment of anticoagulants and the like onto biomater

1990-07-18

1991-10-29

Page, Thurman K.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

523112, 435180, 514822, 424422, 424423, C08G 6348, C08G 6391, C12N 1106, A61F 202

Patent

active

050617508

ABSTRACT:
A substrate for medical devices and a process for making the substrate is provided, the substrate having on at least part of its surface a blood-compatible surface produced by coupling a physiologically active substance to the surface. The physiologically active substance is one having an inhibitory effect on the formation of blood clots and/or is capable of breaking down blood clots formed. The physiologically active substance is bonded to a polyacid, and the polyacid is attached to the surface by a covalent bond.

REFERENCES:
patent: 3826678 (1974-07-01), Hoffman et al.
patent: 4378435 (1983-03-01), Takagi et al.
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4634762 (1987-01-01), Feijen et al.

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