Coupling reagent for peptide synthesis

Details Coupling reagent for peptide synthesis Coupling reagent for peptide synthesis

1991-05-21

1992-11-24

Brust, Joseph P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyano single bonded and nitrogen or phosphorus double bonded...

558384, C07C25515, C07C25330

Patent

active

051663945

ABSTRACT:
Novel compounds of the formula I ##STR1## in which X is an anion, and a process for the preparation thereof, are described. Compounds of the formula I are used as coupling reagents in peptide synthesis.

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Kogler, et al., Tetrahedron Letters, vol. 30, No. 15, pp. 1931-1934, (1989).
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Loubinoux, et al., Tetrahedron Letters, vol. 30, No. 15, pp. 1939-1942 (1989).
Konig et al., "Perchloric Acid in Peptide Chemistry" Peptides 1990; pp. 143-145 (1991).
Dourtoglou et al., Synthesis, pp. 572-574 (1984).
Itoh, Chemistry and Biology of Peptides, pp. 365-367 (1972).
Knorr et al., Tetrahedon Letters, vol. 30, No. 15, (1989) pp. 1927-1930.

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