Coupling reaction involving a Grignard and allylic halide

Chemistry of hydrocarbon compounds – Unsaturated compound synthesis – From nonhydrocarbon feed

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585469, C07C 126

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active

042924596

ABSTRACT:
Disclosed is a process for the coupling of a Grignard reagent RMgX with an allylic halide in the presence of a dipolar aprotic solvent wherein the improvement, for obtaining improved yield and selectivity, comprises adding a catalyst to said Grignard or allylic halide and then carrying out the coupling reaction by the addition of the Grignard reagent to the allylic halide, said reaction being characterized by the displacement at the gamma position (relative to the halide) of the allylic halide with R of the Grignard reagent, migration of the allylic double bond in the direction of the halogen atom and loss of halogen. The present invention also resides in the discovery of certain novel procedures for the synthesis of Vitamin E. Specific embodiments of this aspect of the invention reside in the syntheses of 6,7-dehydrophytol, 10,11-dihydrofarnesene, phytone, hexahydropseudoionone, and related compounds as precursors for Vitamin E.

REFERENCES:
patent: 3948803 (1976-04-01), Carney
Kharasch et al., "Grignard Reactions of Nonmetallic Substances" (1954), Prentice-Hall, New York pp. 1157 to 1165.
Tamura et al., "Journal of Organometallic Chemistry", 42 (1972) pp. 205 to 210.

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