Coupling product between tryptamine and an alpha-amino acid,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S414000, C514S419000, C548S312100, C548S455000

Reexamination Certificate

active

07094796

ABSTRACT:
The purpose of the invention concerns a family of pseudodipeptides which are coupling products between tryptamine, an indole-primary amine, and a selection of alpha-amino acids, the said pseudodipeptides having the following general formula (I):in which:R1represents a hydrogen atom, an acyl or acyloxy radical,R2represents the side chain of an alpha-amino acid chosen among L-glutamic acid, L-arginine, L-cysteine, L-methionine, L-histidine, L-tryptophan, L-tyrosine.The present invention also concerns the process for the preparation of said products as well as their applications in neurocosmetic compositions or as active substances on the cutaneous nervous system.

REFERENCES:
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patent: WO 0072815 (2000-07-01), None
patent: WO 03072124 (2003-04-01), None
Search Report (Mar. 1, 2004) from French Patent Application 0215741 (Rapport De Recherche Préliminaire, INPI Institute National de la Propriete Industrielle).
Search Report (Mar. 1, 2004) from European Patent Application 03022092 (Rapport De Recherche Europeenne, Office européen des Brevets).
Patricia Melnyk et al.: “A new diastereoselective synthesis of cis l-aminoindoloquinolizidine”Tetrahedron Letters, vol. 34, No. 32, 1993, pp. 5085-5088.
Mueller, J. Constanze D., et al.: “Non-peptidic cysteine derivatives as inhibitors of matrix metalloproteinases”Biological Chemistry, vol. 378, No. 12, (1997), pp. 1475-1480.
Jean-Francois Nicolay, Isabelle Imbert: “Targeting the cutaneous nervous network”Cosmetics&Toiletries, vol. 118, No. 7, (2003) pp. 37-40, 42, 44.

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