Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1983-07-05
1985-09-17
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
422 57, 436 63, 436 94, 935 78, G01N 3350
Patent
active
045421021
ABSTRACT:
A solid support capable of binding a nucleic acid thereto upon suitable irradiation, comprising (a) a solid substrate, (b) a member selected from the group consisting of a furocoumarin, a phenanthridium halide, and photochemically reactive derivatives thereof, and (c) a divalent radical chemically linking the substrate and the member (b). Specifically, a hydroxy group-containing solid substrate such as nitrocellulose paper is linked via a bifunctional reagent such as cyanogen bromide or 1,4-butanediol diglycidyl ether to an amino-substituted angelicin or psoralen or phenanthridinium bromide which in turn is photochemically linked to a nucleic acid. This is capable of hybridizing with other nucleic acid fragments and is thereby useful in diagnostic assays.
REFERENCES:
patent: 4302204 (1981-11-01), Wahl
patent: 4358535 (1982-11-01), Falkow
Chemical Abstracts I, 86:134373h, (1977).
Chemical Abstracts II, 88:69689r, (1978).
Chemical Abstracts III, 96:31231n, (1982).
Chemical Abstracts IV, 97:195359g, (1982).
Crothers Donald M.
Dattagupta Nanibhushan
Marantz Sidney
Molecular Diagnostics, Inc.
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