Coupling method using selective amination of maleimide

Details Coupling method using selective amination of maleimide Coupling method using selective amination of maleimide

1993-03-10

1994-02-01

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20740

Patent

active

052833445

ABSTRACT:
The instant invention is a method of coupling compounds comprising the steps of:

REFERENCES:
patent: 4994385 (1991-02-01), Bieniarz et al.
patent: 5204366 (1993-04-01), Lavanish et al.
Brewer, C. F. et al., (1967), "Evidence for Possible Nonspecific Reactions between N-Ethylmaleimide and Proteins", Analytical Biochemistry 18, 248-255.
Dell'Arciprete, L. D., et al., (1988), "A C Terminus Cysteine of Diphtheria Toxin B Chain involved in Immunotoxin Cell Penetration and Cytotoxicity", Journal of Immunology 140, No. 7, 2466-2471.
Kitagawa, T., et al., (1976), "Enzyme Coupled Immunoassay of Insulin Using a Novel Coupling Reagent", J. Biochem. 79, No. 1, 233-236.
Myers, D. E., et al., (1989), "The Effects of Aromatic and Aliphatic Maleimide Crosslinkers on Anti-CD5 Ricin Immunotoxins", Journal of Immunolocial Methods, 121, 129-142.

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