Surgery: kinesitherapy – Kinesitherapy – Ultrasonic
Reexamination Certificate
2000-03-21
2002-08-13
Lateef, Marvin M. (Department: 3737)
Surgery: kinesitherapy
Kinesitherapy
Ultrasonic
C604S014000, C604S022000, C600S439000
Reexamination Certificate
active
06432069
ABSTRACT:
Applicants claim benefit of priority of French Application No. 99 03 738 filed Mar. 25, 1999, entitled Coupling Medium For High-Power Utrasound.
BACKGROUND OF THE INVENTION
The present invention relates to the field of ultrasound, and more precisely to the field of powerful ultrasound employed for therapeutic purposes, and notably for creating lesions in tissue.
The use of ultrasound for diagnostic purposes in ultrasound scan apparatus is known; such apparatus generally consists of a simple probe which is applied against the patient. In order to improve ultrasound coupling, the use of a coupling gel between the probe and the patient's skin is known. This gel is applied as a thin layer to the patient's skin before examination starts.
Japanese Patent application 2 92343 discloses a coupling product for ultrasound imaging formed by a matrix of porous material such as polyurethane, containing an aqueous gel such as polyvinylpyrrolidone(PVP).
Ultrasound is also used for therapeutic purposes for destroying concretions, mainly by a mechanical effect(shock waves), or in order to create lesions in the tissue, principally by a thermal effect. The apparatus employed in this invention includes a transducer arranged inside a flexible or rigid enclosure, filled with a coupling liquid, which may be water. The enclosure is applied against the patient close to the region to be treated. If needs be, a coupling gel can be employed between the enclosure and the patient's tissue. The distance of propagation inside the coupling liquid is greater than is the case with a coupling gel for ultrasound scanning.
The following can be cited as examples of ultrasound treatment apparatus consisting of endo-cavitary hypothermia apparatus: French Patent applications serial numbers: 91 02620, 93 09158, 96 08096, 94 01304 or 94 06539; such apparatus is adapted to treat the prostate by endo-rectal methods, and includes a focused therapy probe able to produce tissue heating at the focal point, which leads to tissue necrosis at the focal point.
The invention applies notably to the field of therapeutic treatment of tissue by focused ultrasound and more particularly to the field of destruction of tissue inside an organism by causing elevated temperatures using focused ultrasound. In the general area of focused ultrasound, as is known by those skilled in the art, different types of treatment can be distinguished: the earliest treatment to appear was treatment by lithotripsy, which applies to the destruction of hard bodies. This type of treatment employs shock waves, in other words, brief high-power pulses. Later, it was proposed to treat soft tissue by hyperthermia by heating tissue to temperatures not excessively high, in other words, less than 45° C. Hyperthermia involves sending long ultrasound pulses of lower power towards the tissue to be treated. Finally, treatment of the soft tissue using high intensity focused ultrasound, generally known by the acronym HIFU, is being proposed. HIFU treatment consists in heating tissue to elevated temperatures typically greater than 45° C. Focused ultrasound treatment at high intensity represents an effective means for creating lesions by necrosis from coagulation in biological tissue with a view to treating localized tumors.
Beyond a certain power threshold, ultrasound creates cavitation phenomena in the media through which it is propagated. Apart from the mechanical effects of cavitation, the bubbles created by cavitation are an obstacle to ultrasound propagation. The cavitation phenomenon becomes increasingly serious as ultrasound power increases. Such cavitation phenomena are not produced in ultrasound scanning, as the intensity of the ultrasound employed is below the cavitation threshold of the coupling agent. Additionally, in ultrasound scanning applications, the thickness of coupling agent is such that ultrasound absorption by the coupling gel is of secondary importance.
In the case of therapy devices that include additional monitoring by ultrasound scanning, as in the applications mentioned above, the presence of bubbles brought about by cavitation can additionally hinder imaging or may simply be a problem for distance measurement even if the cavitation bubbles do not present a problem for the passage of therapy ultrasound. Notably, when measuring distances by ultrasound in A-mode, the cavitation bubbles create spurious echoes which interfere with and falsify measurement.
U.S. Pat. No. 5,445,813 to Schneider et al. discloses an injectable suspension based on micro-bubbles used as a contrast agent for ultrasound scanning. This suspension acts as a reflector towards ultrasound; it is echogenous.
This use teaches against the aims of the present invention as it tends to increase absorption by ultrasound of low power. In this invention, use of decreasing cavitation brought about by the high-power ultrasound is proposed.
A Rajulu et al., in
Ultrasonic studies in solutions of polyvinylpyrrolidone,
Acustica (1991), volume 75 No. 3, pages 213-6 evaluates the properties of aqueous solutions of PVP for determining variations in adiabatic compressibility as a function of temperature, viscosity, and molar ratio between polyvinylpyrrolidone and the solvent.
K. Rao et al.,
Acoustical parameters of polyvinylpyrrolidone solutions
, Acta polym. (1989), vol. 40 No. 12, pages 743-6 demonstrate the presence of a complex with H-shaped bonds for aqueous solutions of PVP at varying concentrations, starting from a study of the speed of propagation of ultrasound, of viscosity and refractive index.
S. Kato et al.,
Ultrasonic absorption in aqueous polyvinylpyrrolidone solutions
, Nippon Kagaku Kaisha (1974), Vol. 10, discusses the behavior in absorption of aqueous solutions of PVP between 5 and 130 MHz and between 10 and 40° C.
These documents neither disclose nor suggest the use of aqueous solutions of PVP or another hydrophilic polymer as a coupling medium for high-power ultrasound.
U.S. Pat. No. 5,078,149 discloses an ultrasound coupling device having a recipient containing a polymer gel; the coupling device is designed to be arranged between an ultrasound scan probe and the patient to be investigated. One of the polymer gels proposed in that reference is a 3-dimensionally radiation-hardened PVP solution. That reference, however, only mentions applications for ultrasound scanning, and does not disclose or suggest the problem of cavitation, its solutions, or applications involving treatment by high-power ultrasound.
Additionally, high-power transducers need to be cooled. Accordingly, the coupling medium that is in contact with them should be pumpable (liquid), which excludes viscous media.
There is consequently a need for a liquid coupling medium which is suitable for transmission of ultrasound at the frequencies and the energy levels typically employed for ultrasound therapy treatment, which makes it possible to avoid as much as possible cavitation phenomena. Preferably, such a coupling medium should have an absorption which is as low as possible in the frequency range of the ultrasound employed.
This problem occurs notably in hyperthermia apparatus but is also encountered in other treatment apparatus using high-power ultrasound.
The present invention discloses a solution to this problem.
SUMMARY OF THE INVENTION
More precisely, there is a provided a coupling medium for high-power ultrasound comprising a liquid aqueous solution of a hydrophilic polymer. A preferred hydrophilic polymer is polyvinylpyrrolidone.
The molecular weight of the hydrophilic polymer is preferably between 10,000 and 100,000. In a preferred embodiment, the amount of polymer is between 10 and 50 g/l.
The present invention also provides an ultrasound therapy apparatus, which includes a therapy transducer adapted to transmit high-power ultrasound, arranged in an enclosure filled with the above coupling medium. The apparatus preferably includes an ultrasound generator coupled to the transducer, which transmits ultrasound in a frequency range between 1 and 5 MHz, and preferably between 2 and 3 MHz. In one em
Blanc Emmanuel
Godo Joseph
Lateef Marvin M.
Lin Jeoyuh
Technomed Medical Systems S.A.
Welsh & Katz Ltd.
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