Coupling agents for radiolabeled antibody fragments

Details Coupling agents for radiolabeled antibody fragments Coupling agents for radiolabeled antibody fragments

1984-10-10

1987-04-21

Nucker, Christine M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424 11, 424 9, 436512, C07D20740, A61K 4300, A61K 4900, G01N 33563

Patent

active

046598391

ABSTRACT:
Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.

REFERENCES:
patent: 4214048 (1980-07-01), Kitagawa
patent: 4308249 (1981-12-01), Frank et al.

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