Coupling agents and sterically hindered disulfide linked conjuga

Details Coupling agents and sterically hindered disulfide linked conjuga Coupling agents and sterically hindered disulfide linked conjuga

1992-02-14

1993-08-31

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558254, 564500, 564501, C07D20746, C07C32104

Patent

active

052410781

ABSTRACT:
This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1.degree. and 2.degree. amines or reactive thiols that are present on biological and organic materials. The coupling agents are useful for making conjugates containing a sterically hindered linkage.

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