Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1983-01-31
1984-07-10
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
424 85, 424 88, 424 92, 260112R, A61K 3940, A61K 39095, A61K 39102, C07G 700
Patent
active
044592868
ABSTRACT:
Haemophilus influenzae type B polysaccharide is coupled through a spacer to a serotype outer membrane protein from Neisseria meningitidis. This conjugate has enhanced antigenicity and immunogenicity relative to the unconjugated polysaccharide.
REFERENCES:
patent: 4220717 (1980-09-01), Kuo
patent: 4271147 (1981-06-01), Helting et al.
Schneerson et al., New Dev. with Hum. & Vet. Vaccines, pp. 77-97, 1980.
Anderson et al., Inf. & Imm., vol. 15, pp. 472-477, 1980.
Helting et al., Actapath. Microbiol. Scand. Sect. C., vol. 89, pp. 69-78, 1982.
Schneerson et al., J. Exp. Med., vol. 152, pp. 361-376, 1980.
Rosenberg et al., J. Biol. Chemistry, vol. 236, pp. 2845-2849, 1961.
Hilleman Maurice R.
Tai Joseph Y.
Tolman Richard L.
Vella Philip P.
Elder Richard A.
Hazel Blondel
Lopez Gabriel
Merck & Co. , Inc.
Pfeiffer Hesna J.
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