Counting system for fluorescent molecules

Details Counting system for fluorescent molecules Counting system for fluorescent molecules

2006-02-09

2008-10-21

Porta, David P. (Department: 2884)

Radiant energy

Luminophor irradiation

C250S459100

Reexamination Certificate

active

07439522

ABSTRACT:
Single molecule measurement is conducted by propagating a laser light under multiple reflection between two substrates constituting a flow channel for flowing a sample solution, exciting target molecules in the sample, detecting one-dimensional images of generated fluorescence by a one-dimensional detection portion, synthesizing two-dimensional images from the obtained one-dimensional images by a data synthesizing portion and measuring the concentration of target molecules in the sample solution by counting the number of target molecules based on the two-dimensional images, thereby measuring the concentration of the target molecules in the sample solution. These constitutions for single molecule measurement lead to high precision determination of a micro-amount of a biological material.

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Electophoretic Quantitiation of Nucleic Acids without Amplification by Single-Molecule Imaging; Oct. 1, 2002; vol. 74, No. 19; Analytical Chemistry; United States.

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