Counteracting bioprosthetic calcification

Details Counteracting bioprosthetic calcification Counteracting bioprosthetic calcification

2007-01-02

2007-01-02

Gupta, Y (Department: 1751)

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

C623S001210, C623S002220, C623S003100, C623S004100, C623S007000, C623S009000, C623S010000, C623S011110, C623S017120, C623S013190, C623S014110, C514S021800

Reexamination Certificate

active

10336857

ABSTRACT:
Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis calcification. The anti-calcification agent in question includes a polyphosphonate compound that contains a functional group, which serves as a reaction site between the polyphosphonate and a polyepoxide. The functional group is reactive enough to dominate the reaction between the polyphosphonate and the polyepoxide, thereby excluding the chelating oxygen atoms of polyphosphonate from the reaction, protecting their anti-calcification ability. Furthermore, the high reactivity of the functional group allows the polyphosphonate to attach to the polyepoxide more completely, which improves the calcification resistance of bioprosthetic material with which the polyepoxide is crosslinked.

REFERENCES:
patent: 5338731 (1994-08-01), Breuer et al.
patent: 5674298 (1997-10-01), Levy et al.
patent: WO 01/58503 (2001-08-01), None
Alferiev et al., J. Polymer Sci., Part A (Polymer Chemistry) 39:105 (2001).

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