Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-12
2005-07-12
Lukton, David (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S530000, C514S427000
Reexamination Certificate
active
06916846
ABSTRACT:
Coumermycin analogs of general formula I:wherein X, a linking group, is selected from the group consisting of alkyl, aryl, diaryl, substituted alkyl, substituted aryl, alkyl with hereroatoms in the chain, heteroaryl, cyclic and bicyclic alkyl, and a combination of alkyl, aryl and heteroaryl substituents. The compounds are suitable for use as chemical dimerizers of chimeric proteins.
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M. A. Farrar et al., Activation of the Raf-1 Kinase Cascade by Coumermycin Induced Dimerization, Nature, vol. 383, pp. 178-181, Sep. 12, 1996.
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Farrar Michael A.
Olson Steven H.
Perlmutter Roger M.
Slossberg Llnon H.
Ayler Sylvia A.
Camara Valerie J.
Lukton David
Merck & Co. , Inc.
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