Coumarins connected via an oxyalkyl group with a piperidine ring

Details Coumarins connected via an oxyalkyl group with a piperidine ring Coumarins connected via an oxyalkyl group with a piperidine ring

1979-12-17

1982-05-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424258, 546157, 546194, 546196, 549289, A61K 31445, C07D31106, C07D31116

Patent

active

043305490

ABSTRACT:
The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof.
The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.

REFERENCES:
patent: 3275658 (1966-07-01), Lednicer
patent: 3637759 (1972-01-01), Weichet et al.
patent: 4093631 (1978-06-01), Gardner
patent: 4146539 (1979-03-01), Gardner
patent: 4205082 (1980-05-01), Ferrini
patent: 4210753 (1980-07-01), Tominaga et al.
patent: 4264599 (1981-04-01), Eichenberger et al.
patent: 4281132 (1981-07-01), Ward
patent: 4288442 (1981-08-01), Friebe et al.
Roesch, et al., Chemical Abstracts, vol. 88, (1978) 44917a, abstract of Monogr. Allergy 1977, 164-168.

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