Coumarin spherules/beads having unique morphology

Details Coumarin spherules/beads having unique morphology Coumarin spherules/beads having unique morphology

1995-03-16

1997-12-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424470, 424464, A61K 914

Patent

active

056933428

ABSTRACT:
Free-flowing, non-agglomerating and attrition resistant, substantially spherical solid beads/spherules of a coumarin compound, advantageously having a particle size ranging from 100 .mu.m to 2,000 .mu.m, a loose bulk density ranging from 0.25 to 0.8 and a compressive strength ranging from 500 to 10,000 N/m.sup.2, dissolve rapidly in ethanol and are conveniently prepared by prilling/fragmenting a melt of the coumarin compound into a stream of a cooling gas.

REFERENCES:
patent: 4946359 (1990-08-01), Christen
patent: 5260072 (1993-11-01), Roche et al.
patent: 5283065 (1994-02-01), Doyon et al.

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