Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-08-11
1999-07-13
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544295, 544360, 544376, 546193, 546196, 546256, 5462831, 514256, 514320, 514337, A61K 31495, A61K 31505, C07D23932, C07D24120
Patent
active
059227192
ABSTRACT:
This invention relates to compounds that are antagonists of dopamine D4 receptors, to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors, and to pharmaceutically acceptable compositions that contain a dopamine D4 receptor antagonist.
REFERENCES:
patent: 5550129 (1996-08-01), Noldner et al.
Gazi et al., "The agonist activites of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor," British Journal of Pharmacology, vol. 124, pp. 889-896, 1998.
Reynolds, "The Importance of Dopamine D4 Receptors in the Action and Development of Antipsychotic Agents," Drugs, vol. 51, No. 1, pp. 7-11, 1996.
Kulagowski et al., "Dopamine D4 Receptor Antagonists," Current Pharmaceutical Design, vol. 3, pp. 355-366, 1997. Increased in Schizophrenia," Society of Biological Psychiatry, vol. 42, pp. 648-654, 1997.
Rubenstein et al., "Mice Lacking Dopamine D4 RecptorsAre Supersensitive to Ethanol, Cocaine, and Methamphetamine," Cell, vol. 90, pp. 991-1001, 1997.
Johnson Stephen Joseph
Kesten Suzanne Ross
Wise Lawrence David
Wustrow David Juergen
Crissey Todd M.
Kessinger Ann M.
Shah Mukund J.
Warner-Lambert & Company
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