Coumarin derivatives, pharmaceutical compositions containing the

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549289, A61K 3137, C07D31106

Patent

active

047375175

ABSTRACT:
A compound having the formula: ##STR1## wherein R.sub.1 is halogen or a substituted or unsubstituted hydrocarbon group; R.sub.2 R.sub.6 and R.sub.7, which may be the same or different, each represents hydrogen or a substituted or unsubstituted hydrocarbon group, or R.sub.6 and R.sub.7 taken together may represent a hetero group having one or more hetero atoms; R.sub.3 and R.sub.4 which may be the same or different each represents a substituted or unsubstituted hydrocarbon group; or R.sub.3 and R.sub.4 taken together may represent an alkylene group or a hetero group having one or more hetero atoms and R.sub.5 is hydrogen, a substituted or unsubstituted hydrocarbon group, halogen or a free or protected hydroxy group, or a pharmaceutically acceptable salt thereof. The compounds have antiaggregating properties.

REFERENCES:
patent: 3515721 (1970-06-01), Ritter et al.
patent: 3795685 (1974-05-01), Scanesi
patent: 3880885 (1975-04-01), Houliban et al.
patent: 4296039 (1981-10-01), della Valle
patent: 4321270 (1982-03-01), Sunseen
patent: 4362741 (1982-12-01), della Valle
patent: 4452811 (1984-06-01), della Valle
CA 92:146659t p. 582 (1980) Rao et al. Synthesis of Pyranobenzisoxazol-5-ones.
CA 60:15820(g) Mehta et al., Bechnan rearrangement of Oximes of C-acylcoumarins (1964).
Sianesi et al. CA: 77(13):88305(b) 1972, [(Dimethylamino) Cethyl]Coumarins and a Chromenes.
Mathur et al., CA 89:157317u (1978), Antitumor Activity of N-Arylmethyl Nitrogen Mustards.
Shah I et al., 84:30814v (1976), p. 438 Mannich Bases from Halomethyl Coumarins.
Shah II et al. 84:30815w (1976) p. 438 Nitrogen Mustards from Coumarin Derivatives.
Hinshaw et al., CA:98:218134s Fluoresent Chelates & Specific Bending Agents (1983) and vol. 98 Formula Index C.sub.26 H.sub.23 N.sub.3 O.sub.14.
"Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung", L. Zacharski et al., JAMA, Feb. 27, 1981, vol. 245, No. 8, pp. 831-835.
"Rationale and Experimental Design for the VA Cooperative Study of Anti-Coagulation (Warfarin) in the Treatment of Cancer", L. Zacharski et al., reprinted from Cancer, vol. 44, No. 2, Aug. 1979, pp. 732-741.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Coumarin derivatives, pharmaceutical compositions containing the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Coumarin derivatives, pharmaceutical compositions containing the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Coumarin derivatives, pharmaceutical compositions containing the will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1429598

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.