Coumarin derivatives for use as nucleotide crosslinking reagents

Details Coumarin derivatives for use as nucleotide crosslinking reagents Coumarin derivatives for use as nucleotide crosslinking reagents

1989-04-05

1992-01-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 179, 536 181, 536 22, 536 27, C07H 19067

Patent

active

050829343

ABSTRACT:
A photoactivatible nucleoside analogue is disclosed, comprising a coumarin moiety linked through its phenyl ring to the 1-position of a ribose or deoxyribose sugar moiety. The resulting nucleoside analogue is typically used as a photocrosslinking group when inserted into a polynucleotide as a replacement for one or more of the complementary nucleoside bases present in a probe used in a hybridization assay.

REFERENCES:
patent: 4826967 (1989-05-01), Glass

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