Coumarin derivatives as protease inhibitors and antiviral agents

Details Coumarin derivatives as protease inhibitors and antiviral agents Coumarin derivatives as protease inhibitors and antiviral agents

1993-11-19

1996-04-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549285, A61K 3135

Patent

active

055103758

ABSTRACT:
The present invention relates to novel coumarin derivatives and related compounds which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The coumarin derivatives are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized coumarins and of related structures.

REFERENCES:
patent: 3810922 (1974-05-01), Dunbar
patent: 5179107 (1993-01-01), Afonso et al.
T. Robins et al., J of Acquired Immune Deficiency Syndromes, 1993, 6:162-170.
C. Debouck, et al., Drug Development Research, 1990, 21:1-17.
L. H. Pearl, et al., Nature, 1987, 329:351-354.
J. R. Huff, J Med Chem, 1991, 34(8):2305-2314.
R. C. Gallo, et al., Scientific American, 1988, 259(4):41-48.
J. Leis, et al., ASM News, 1990, 56(2):77-81.
B. Zhao, et al., Biochemistry, 1993, 32:13054-13060.
K. Appelt, Perspectives in Drug Discovery, 1993, 1:23-48.
L. H. Phylip, Biochem & Biophys Res Communications, 1990, 171(1):439-444.
S. Galpin, et al., Antiviral Chemistry & Chemotherapy, 1994, 5(1):43-45.
N. E. Kohl, et al., Proc Natl Acad Sci, USA, 1988, 85:4686-4690.
C-F. Perno, et al., J Infectious Diseases, 1993, 168:1148-56.
D. J. Kempf, et al., J Med Chem, 1990, 33(10):2687-2689.
H. Mitsuya, J Enz Inhib, 1992, 6:1-8.
Antiviral Agents Bulletin, 1993, 6(6):163.
Antiviral Agents Bulletin, 1994, 7(3):69-70.
D. Richman, "Control of Virus Diseases," 45th Symposium of the Society for General Microbiology, 1990, 261-313.
H. Toh, et al., Nature, 1985, 315:691.
J. Kay, et al., Biochim. Biophys. Acta 1: 1990, 1048.
C. Cameron, et al., J. Biological Chem. 168, 1993, 11711-72.
M. Graves, Structure and Function of the Aspartic Proteases 1991, 395-405.
C. Peng, et al., J. Virol., 63: 1989, 2550-2556.
N. Kohl, et al., Proc. Nat. Acad. Sci. USA, 85:1988, 4689-90.
J. C. Craig, et al, Antiviral Research, 16:1991, 295-305.
A. G. Tomasselli, et al., Chimica Oggi, 9:1991, 6-27.
T. Meek, J. Enzyme Inhibition, 6: 1992, 65-98.
R. Nagorny, et al, AIDS, 7:1993, 129-130.
D. P. Fairlie, et al., Biochem. Biophys. Res. Comm., 188: 1992, 631-637.

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