Coumarin derivatives as ion channel openers

Details Coumarin derivatives as ion channel openers Coumarin derivatives as ion channel openers

2009-11-24

2011-11-29

Kosar, Andrew D. (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S290000

Reexamination Certificate

active

08067619

ABSTRACT:
The present invention is directed to coumarin derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

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Edwards, G. et al.: “Structure—activity relationships of K+channel openers”; TiPS, Oct. (1990) 11: 417-422.
Sato, H. et al.: “Vasorelaxant Activity of 2-fluoroalkyl-6-nitro-2H-1-Benzopyran-4-carbothioamide and—carboxamide K+Channel Openers”; Bioorganic & Med. Chem. Ltrs. (1995) 5(3): 233-236.
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Database Chemcats [Online], Chemical Abstracts Serivce, Columbus, Ohio, US; XP002392765; Enamine Screening Library, Jan. 24, 2006. Abstract.
PCT International Search Report relating to International Patent Application No. PCT/2006/001927; date of mailing Aug. 10, 2006.
PCT Written Opinion for International Application No. PCT/2006/001927.

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