Coumarin derivatives and method for synthesizing 5'-methyl psora

Details Coumarin derivatives and method for synthesizing 5'-methyl psora Coumarin derivatives and method for synthesizing 5'-methyl psora

1982-03-09

1983-08-09

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549289, C07D40502

Patent

active

043980317

ABSTRACT:
Two species of a coumarin derivative are disclosed, both of which may be produced from a 7-hydroxycoumarin precursor. The one species is an oxime and the other is a .beta.-haloallyl ester.
A method for making a psoralen compound in high yield comprises treating these coumarin derivatives with an acid to fuse a furan ring thereto, and recovering a 5'-methyl psoralen therefrom. The 5'-methyl psoralen may be produced in up to about 70% overall yield with respect to the 7-hydroxycoumarin precursor.

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