Coumarin compounds and their use for treating cancer

Details Coumarin compounds and their use for treating cancer Coumarin compounds and their use for treating cancer

2009-06-10

2011-11-15

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S375000, C546S146000, C546S197000, C548S454000, C549S387000

Reexamination Certificate

active

08058427

ABSTRACT:
Coumarin compounds of formula (I):wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a method for treating cancer with coumarin compounds.

REFERENCES:
patent: 4542102 (1985-09-01), Dattagupta et al.
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4794073 (1988-12-01), Dattagupta et al.
patent: 4853327 (1989-08-01), Dattagupta
patent: 4950588 (1990-08-01), Dattagupta
patent: 4994263 (1991-02-01), Lang et al.
patent: 5372929 (1994-12-01), Cimino et al.
patent: 5565320 (1996-10-01), Cimino et al.
patent: 6242188 (2001-06-01), Dattagupta et al.
patent: 6379930 (2002-04-01), Dattagupta et al.
patent: 6448047 (2002-09-01), Dattagupta et al.
patent: 2001/0031473 (2001-10-01), Dattagupta et al.
patent: 2002/0061537 (2002-05-01), Dattagupta et al.
patent: 0130523 (1988-06-01), None
patent: 0210449 (1993-07-01), None
N.A. Farag. Bull. Fac. Pharm. Cairo Univ., vol. 44, No. 1 (2006).
Sibirtsev et al. Biochemistry (Moscow), vol. 70, No. 7, 2005.
Geetanjali et al., “Synthesis of 2-Aroyl-3-phenylfuranobenzopyrones,” Indian Journal of Chemistry 22B:164-165 (1983).
Pathak et al., Production of Active Oxygen Species1O2and O2) By Psoralens and Ultraviolet Radiation (320-400nm), Biochimica et Biophysica Acta 798:115-126 (1984).
Guilet et al., “Novel Cytotoxic 4-Phenylfuranocoumarins fromCalophyllum dispar” J. Nat. Prod/ 64:563-568 (2001).
Bhayani et al., “Furocoumarin Studies. Part-1. New Synthesis of 4-Methylangelicin and Angelicin,” J. Indian Chem. Soc. 67:71-72 (1990).
Chaturvedula et al., “New Cytotoxic Coumarins and Prenylated Benzophenone Derivatives from the Bark ofOchrocarpos punctatusfrom the Madagascar Rainforest,” J. Nat. Prod. 65:965-972 (2002).
Caffieri et al., “Difurocoumarins, Psoralen Analogs: Synthesis and DNA Photobinding,” Z. Naturforsch 50b:1257-1264 (1995).
Baccichetti et al., “New Benzopsoralen Derivative: T2 Phage Inactivation,” Med. Biol. Environn., 23(1):7-11 (1995).
Isaacs et al., “Post-PCR Sterilization: Development and Application to an HIV-1 Diagnostic Assay,” Nuclei Acids Research, vol. 19, No. 1:109-116 (1990).
Versailles et al., “Photochemical Sterilization of 3SR Reactions,” PCR Methods and Applications, 3:151-158 (1993).
Zmudzk et al., “Activation of the Human Immunodeficiency Virus Promoter by UVA Radiation in Combination with Psoralens or Angelicins,” Photochemistry and Photobiology, 58(2):226-232 (1993).
Miolo et al., “Antiretroviral Activity of Furocoumarins Plus UVA Light Detected by a Replication-Defective Retrovirus,” Journal of Photochemistry and Photobiology, 26:241-247 (1994).
Joshi et al., “Production on Singlet Oxygen and Superoxide Radicals by Psoralens and Their Biological Significance,” Biochemical and Biophysical Research Communication, 112(2):638-646 (1983).
Chen et al., “Photosensitized Cross-Linking and Cleavage of pBR322 and M13 DNA: Comparison 4,4;′,6-trimethylangelicin and 3-carbethoxypsoralen,” J. Photochen. Photobiol. B: Biol., 22:51-57 (1994).
Czyz et al., “Comparison of Inhibitory Effects of Mono- and Diadducts of Furocoumarins on the Transcriptional Template Activity of Phage T7 DNA,” Studia Biophysica, 135(3):147-154 (1990).
van Iperen et al., “The Lack of Efficacy of 4,6,4′-Trimethylangelicin to Induce Immune Suppression in an Animal Model for Photopheresis: A Comparison with 8-MOP,” Photochemistry and Photobiology, 63(5):577-582 (1996).
Rao et al., “Studies on the Synthesis of Furocoumarins. Part-XXX. A Reinvestigation of Claisen Rearrangement of 7-Cinnamyloxy-4-methylcoumarin,” J. Indian Chem. Soc. 69:203-206 (1992).
Kawase et al., “Synthetic Studies on the Benzofuran Derivatives. VII. A New Synthesis of Angelicin and 4-Methylangelicin,”vol. 35, No. 1, pp. 149-151 Jan. 1962.
Rao et al., “Furocoumarins: Part 34-Synthesis and stereochemistry of Dihydrofurocoumarins,” Indian Journal of Chemistry, 31B:488-491 (1992).
Traven et al., “Synthesis of New Difurocoumarins,” Chemistry of Heterocyclic Compounds, 39(7):866-871 (2003).
Sibirtsev et al., “Spectral Study of Interactions of 4,8,4—Trimethylpsoralen and 4,4—Dinethylangelicin Dyes with DNA,” Biochemistry (Moscow) 70(7):822-832 (2005).
Sibirtsev et al., “Dependence of Fluorescence Properties of Compounds from Psoralen, Angelicin, and Carbazole Series on the Character of Their Terminal Substituents,” Russian Journal of Organic Chemistry, 39(6):881-889 (2003).
V.S. Sibirtsev, “Fluorescent DNA Probes: Study of Mechanisms of Changes in Spectral Properties and Features of Practical Application,” Biochemistry (Moscow), 72(8):1090-1106 (2007).
Tolmachev et al., “New Synthesis of 8-Alkoxycarbonylangelicins” Russian Journal of Organic Chemistry, 37(7):1008-1012 (2001).
Salvi et al., “Studies in Furan Derivatives: Part V. Syntheses of Some Furocoumarins,” Jour. Indian Chem. Soc., 45(5):439-445 (1968).
Traven et al., “Electronic Structure of P Systems: XX. Electronic Structure a Keto-Enoltautomerism of dihydrofuro[2,3-h]coumarin-9-ones by photoelectron spectroscopy,” Russian Journal of General Chemistry, 71(6)m pp. 945-949 (2001).
Santana et al., “Furocoumarins in Medicinal Chemistry. Synthesis, natural occurrence and biological activity,” Current Medicinal Chemistry, 11(24) pp. 3239-3261 (2004).

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