Costunolide derivatives

Details Costunolide derivatives Costunolide derivatives

2007-08-14

2009-02-10

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07488836

ABSTRACT:
A compound of the following formula:wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating autoimmune disease, cancer, or atherosclerosis with such a compound.

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Macias et al. Tetrahedron (2004), 60(38), 8477-8488.
Choi et al. STN Accession No. 2002:935701, Document No. 138:378745, Abstract of Biological & Pharmaceutical Bulletin (2002), 25(11), 1446-1450.
El-Feraly, STN Accession No. 1985:21216, Document No. 102:21216, Abstract of Phytochemistry (Elsevier) (1984), 23(10), 2372-4.
Kang et al., “Costunolide Inhibits Interleukin-1β Expression by Down-Regulation of AP-1 and MAPK Activity in LPS-Simulated RAW 264.7 Cells,” Biochemical and Biophysical Research Communication, 313:171-177 (2004).
Synthesis of melampolides and cis,cis-germacranolides as natural herbicide models; Francisco A. Macias, Raul F. Velasco, Jose A. Alvarex, Diego Castellano and Juan C.G. Galindo; 2004 Elsevier Ltd.; 8477-8488.

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