Cosmetic skin-renewal-stimulating composition with long-term irr

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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Details

514847, 514859, A61K 700, A61K 748

Patent

active

056163320

ABSTRACT:
A cosmetic skin-renewal stimulating composition suitable for daily use by consumers and providing anti-aging benefits with control of delayed irritation. The invention adds small quantities of a naturally occurring small-molecule, biologically active, aliphatic aminodiol lipid, for example sphingosine, to cosmetics incorporating a skin-renewal stimulating acid, for example lactic, hydroxybenzoic or retinoic acid, to provide control of deferred hyperproliferative allergenicity induced by the skin-renewal stimulating acid. Comparative data show a beneficial control of long-term irritation induced by several weeks of daily use of a variety of skin-renewal stimulating acids. The novel activity is displayed by sphingosine alone among several classes of biologically active skin lipids, in a selective and surprising manner. The results suggest applicability of the invention to wider classes of cell-proliferation agents for the control of deferred hyperproliferative allergenicity.

REFERENCES:
patent: 4105783 (1978-08-01), Yu
patent: 5002760 (1991-03-01), Katzer
patent: 5190876 (1993-03-01), Merrill
patent: 5238965 (1993-08-01), Piazza
patent: 5252604 (1993-10-01), Nagy
Aged Skin, Retinoids, and Alpha Hydroxy Acids by Raoul Hermitte, PhD; "Cosmetics & Toiletries" vol. 107, Jul. 1992 pp. 63-64, 66-67.

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