Drug – bio-affecting and body treating compositions – Extract or material containing or obtained from a...
Reexamination Certificate
2000-12-14
2002-05-28
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract or material containing or obtained from a...
C424S401000, C514S474000, C514S557000
Reexamination Certificate
active
06395281
ABSTRACT:
FIELD OF THE INVENTION
Cosmetic methods and compositions for conditioning human skin by topical application to the skin of cosmetic compositions containing red yeast rice extract.
BACKGROUND OF THE INVENTION
Cosmetic products which improve the appearance of skin are increasingly popular with consumers. Frequently, consumers seek to alleviate or delay the signs of aged or photoaged skin, such as fine lines and wrinkles, dry and sagging skin. Consumers also frequently seek other benefits in addition to anti-aging. A frequent, undesirable skin condition is “oily skin,” the condition which results from the excessive amount of sebum on the skin. Sebum is skin oil which is produced by sebocytes (cells of the sebaceous glands in the skin) and is then secreted to the skin surface. Oily skin is associated with a shiny, undesirable appearance and a disagreeable tactile sensation. Oily skin affects various age groups. Cosmetic actives which are able to provide both anti-aging benefits and sebum control are highly desirable, both from the manufacturer's and consumer's perspective.
In recent years, phytoestrogens (i.e., natural compounds which have estrogen-like activity and which are found in plants) have been increasingly used for cosmetic and therapeutic purposes. Estrogens and synthetic compounds which act like estrogens are known to increase the thickness of the dermal layer and reduce wrinkle formation in the aging skin. Changes in the skin such as skin dryness, loss of skin elasticity and plumpness occurring after menopause are attributed to the lack of estrogen production. Estrogen therapy prevents or slows down many of the changes associated with aging skin (Creidi et al., Effect of a conjugated oestrogen cream (Premarin®) on aging facial skin, Maturitas, 19, p. 211-23, 1994).
Red yeast rice is also known as Monascus sp. Prior art describes a melanin-formation inhibitor in skin care comprising pigment obtained by culturing Monascus mould (JP 6065038 A). Monascus chitinase has been used to prepare chitosan derivatives with tyrosinase inhibiting activity (JP 4210615 A). Cultured extract of the monascus fungus has been claimed in cosmetic material for skin cleansing (JP 1090109 A) and cosmetics for make-up (JP 10194928). U.S. Pat. No. 4,996,196 mentions red yeast rice used in a dehydration process of hydrous matter.
None of the art described above discloses anti-sebum or estrogenic properties of red yeast rice, or any cosmetic compositions containing red yeast rice in combination with acorbates or retinoids presently claimed.
SUMMARY OF THE INVENTION
The present invention includes a skin conditioning composition comprising:
(a) from about 0.001 to about 20 wt. % of red yeast rice extract;
(b) a co-active compound selected from the group consisting of ascorbyl palmitate; sodium ascorbyl phosphate, retinol, retinyl ester, and mixtures thereof; and
(c) a cosmetically acceptable vehicle.
The invention also includes a cosmetic method of controlling oily skin condition and of reducing, preventing or controlling sebum secretion from sebocytes by applying either the red yeast rice extract alone, or the inventive composition, to the skin.
The invention also includes a cosmetic method of stimulating collagen synthesis by fibroblasts in the skin, by applying either the red yeast rice extract alone, or the inventive composition, to the skin.
The invention also includes a cosmetic method of improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility and plumpness by applying either the red yeast rice extract alone, or the inventive composition, to the skin.
The invention also includes a cosmetic method of delivering a phytoestrogen to skin by applying to the skin a cosmetic composition comprising a red yeast rice extract in a cosmetically acceptable vehicle.
The inventive methods and compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.
DETAILED DESCRIPTION OF THE INVENTION
Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word “about.” All amounts are by weight of the composition, unless otherwise specified.
The inventive compositions contain an extract of red yeast rice. Preferably the extract is an organic solvent extract. The organic extracts are prepared by extracting the red yeast rice powder with a solvent by stirring 1 part of red yeast rice with 2 to 5 parts of the solvent for from 4 to 24 hours at room temperature. Suitable solvents are described hereinbelow. The extracts are clarified by filtration and/or centrifugation, then used as is or dried by evaporation (optionally, under vacuum).
Solvents suitable for the preparation of red yeast rice extract for use herein include, but are not limited to: ethanol, butylene glycol, ethylene glycol, propylene glycolmethanol, hexane, chloroform, dichloromethane, DMSO (dimethylsulfoxide) and ethyl acetate. The preferred solvents are dichloromethane, methanol, or ethanol, or DMSO, or glycol:ethanol mixtures in order to maximize activity. The extract may be further concentrated, fractioned, re-extracted or purified, e.g. by organic solvent extraction or by chromatography.
The red yeast rice extract is employed in the present invention in an amount from 0.001 to 20 wt. %, preferably from 0.01 to 10 wt. %, most preferably from 0.01 to 5 wt. %.
Red yeast rice may be obtained from Shangai International Greenmen Trading Company.
According to one aspect of the invention, red yeast rice extract is employed in a variety of cosmetic methods: to deliver estrogenic activity to the skin; to control sebum secretion or oily skin, and to stimulate collagen production by fibroblasts.
According to another aspect of the invention, red yest rice extract is employed in combination with a co-active compound, in order to obtain substantially improved performance. The co-active compound is selected from the group consisting of ascorbyl palmitate; sodium ascorbyl phosphate, retinol, retinyl ester, and mixtures thereof. The preferred co-active compounds are sodium ascorbyl phosphate (due to its chemical stability) or trans-retinol.
The co-active compound may be obtained from Sigma Chemical Co. or BASF.
The term “retinol” includes the following isomers of retinol: all-trans-retinol, 13-cis-retinol, 11-cis-retinol, 9-cis-retinol, 3,4-didehydro-retinol. Preferred isomers are all-trans-retinol, 13-cis-retinol, 3,4-didehydro-retinol, 9-cis-retinol. Most preferred is all-trans-retinol, due to its wide commercial availability.
Retinyl ester is an ester of retinol. The term “retinol” has been defined above. Retinyl esters suitable for use in the present invention are C1-C30 esters of retinol, preferably C2-C20 esters, and most preferably C2, C3, and C16 esters because they are more commonly available. Examples of retinyl esters include but are not limited to: retinyl palmitate, retinyl formate, retinyl acetate, retinyl propionate, retinyl butyrate, retinyl valerate, retinyl isovalerate, retinyl hexanoate, retinyl heptanoate, retinyl octanoate, retinyl nonanoate, retinyl decanoate, retinyl undecandate, retinyl laurate, retinyl tridecanoate, retinyl myristate, retinyl pentadecanoate, retinyl heptadecanoate, retinyl stearate, retinyl isostearate, retinyl nonadecanoate, retinyl arachidonate, retinyl behenate, retinyl linoleate, retinyl oleate, retinyl lactate, retinyl glycolate, retinyl hydroxy caprylate, retinyl hydroxy laurate, retinyl tartarate.
The preferred ester for use in the present invention is selected from retinyl palmitate, retinyl acetate, retinyl l
Bajor John Steven
Januario Thomas Eugene
Mahajan Manisha Narayan
Pillai Sreekumar
Santhanam Uma
Plotkin Ellen
Tate Christopher R.
Unilever Home & Personal Care USA a division of Conopco, Inc.
Winston Randall
LandOfFree
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