Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
1999-03-15
2001-07-03
Russel, Jeffrey E. (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S047000, C424S065000, C424S070140, C424S401000, C514S012200, C514S013800, C514S014800, C514S015800, C514S016700, C514S021800, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000
Reexamination Certificate
active
06255279
ABSTRACT:
The present invention relates to the use of certain vertebrate proteins as substances active against bacteria, Mycota and viruses. In particular embodiments, the present invention relates to cosmetic and dermatological preparations comprising such substances.
The healthy warm-blooded body, in particular the healthy human skin, is populated by a multiplicity of non-pathogenic microorganisms. This so-called microflora of the skin is not only harmless, it is an important protection for defence against opportunistic or pathogenic microorganisms.
Bacteria belong to the prokaryotic single-cell organisms. They can be differentiated roughly according to their shape (sphere, cylinder, curved cylinder) and according to the construction of their cell wall (gram-positive, gram-negative). Finer subdivisions also take into account the physiology of the organisms. Thus aerobic, anaerobic and optionally anaerobic bacteria exist. Some bacteria are of medical importance by virtue of their property as pathogenic microorganisms, others in turn are completely harmless.
Substances active against bacteria have been known for some time. The term “antibiotic”, for example, which is not applicable to all antimicrobially active substances, can be dated to the year 1941, although the first discoveries regarding penicillin had already been made in the year 1929. Antibiotics in the present sense are not suitable for all medicinal applications, even not at all for cosmetic applications, as often the metabolic functions of the warm-blooded body, i.e., for example, of the ill patient, are also adversely affected on administration in any manner.
An object of the present invention was thus to enrich the prior art in this respect, thus in particular to make substances available which are active against gram-positive and/or gram-negative bacteria without the administration of the substances being associated with an unjustifiable adverse effect on the health of the user.
Gram-negative microorganisms are, for example,
Escherichia coli,
Pseudomonas species and also Entero-bacteriaceae, such as, for example
Citrobacter freundii.
Gram-positive microorganisms also play a part in cosmetics and dermatology. In the case of bad skin, for example, besides other influences bacterial secondary infections are of aetiological importance. One of the most important microorganisms which is associated with bad skin is Propionibacterium acnes.
Bad skin and/or comedones adversely affect the well-being of the person affected, however, even in mild cases. As virtually every adolescent is affected by bad skin, in the case of many persons there is a need to remedy this condition.
A particular object of the present invention was thus to find a substance or substance combination active against bad skin or Propionibacterium acnes.
The present invention relates in a further embodiment to cosmetic deodorants. Such formulations are used to eliminate body odour, which is formed when fresh perspiration, which is odourless per se, is decomposed by microorganisms. The customary cosmetic deodorants are based on different active principles.
Both liquid deodorants, for example aerosol sprays, roll-ons and the like and solid preparations, for example deodorant sticks, powders, powder sprays, intimate cleansers etc. are known and customary.
In so-called antiperspirants, the formation of perspiration can be suppressed by astringents—mainly aluminium salts such as aluminium hydroxychloride (aluminium chlorohydrate). Apart from the denaturation of the skin proteins, the substances used for this purpose, however, depending on their dose, intervene drastically in the heat balance of the axillary region and should at best be used in exceptional cases.
By the use of antimicrobial substances in cosmetic deodorants, the bacterial flora on the skin can be reduced. In this process in the ideal case only the odour-causing microorganisms should effectively be reduced. In practice, however, it has turned out that the entire microflora of the skin can be adversely affected. The flow of perspiration itself is not affected by this means; in the ideal case only the microbial decomposition of the perspiration is temporarily stopped.
The combination of astringents with antimicrobially active substances in one and the same composition is also customary. The disadvantages of the two classes of active compound cannot be completely eliminated in this way, however.
Finally, body odour can also be masked by perfumes, a method which is least satisfactory for the aesthetic needs of the consumer, as the mixture of body odour and perfume fragrance smells rather unpleasant.
However, most cosmetic deodorants, and also most cosmetics altogether, are perfumed, even if they comprise deodorizing active ingredients. Perfuming can also be used to increase the consumer acceptance of a cosmetic product or to give a product a certain flair.
The perfuming of active ingredient-containing cosmetic compositions, in particular cosmetic deodorants, however, is often problematical, because active ingredients and perfume constituents occasionally react with one another and can render each other inactive.
Deodorants should fulfil the following conditions:
1) They should cause reliable deodorization.
2) The natural biological processes of the skin must not be adversely affected by the deodorants.
3) The deodorants must be harmless on overdosage or other unintended use.
4) They should not concentrate on the skin after repeated use.
5) They should be capable of good incorporation in customary cosmetic formulations.
A further object of the present invention was thus to develop cosmetic deodorants which do not have the disadvantages of the prior art. In particular, the deodorants should largely protect the microflora of the skin, but selectively reduce the number of microorganisms which are responsible for body odour.
It was furthermore an object of the invention to develop cosmetic deodorants which are distinguished by good skin compatibility. In no case should the deodorizing active principles concentrate on the skin.
A further object of the invention was to develop cosmetic deodorants which harmonize with as large a number as possible of customary cosmetic auxiliaries and additives, in particular with the perfume constituents important especially in deodorizing or antiperspirant formulations.
Yet a further object of the invention was to make available cosmetic deodorants which are active over a relatively long period of time, namely in the order of magnitude of at least half a day, without their action noticeably decreasing.
Finally, an object of the present invention was to develop deodorizing cosmetic principles which can be incorporated as universally as possible into the widest range of administration forms of cosmetic deodorants without being fixed to one or a few specific administration forms.
Fungi [fungus=Latin], Mycota [&mgr;&ngr;&kgr;&eegr;&zgr;=Greek] or mycobionts, as opposed to the bacteria, belong to the eukaryotes. Eukaryotes are organisms whose cells (eucytes), as opposed to those of the so-called prokaryotes (procytes), have a cell nucleus demarcated by a nuclear membrane from the remaining cytoplasm. The cell core contains the genetic information stored in chromosomes.
Representatives of the mycobionts include, for example, yeasts (Protoascomycetes), mold fungi (Plecto-mycetes), mildew (Pyrenomycetes), downy mildew (Phyco-mycetes) and club fungi (Basidiomycetes).
Fungi, not even the Basidiomycetes, are not plant organisms, but like these have a cell wall, cell sap-filled vacuoles and a microscopically readily visible plasma flow. They contain no photosynthetic pigments and are C-heterotrophic. They grow under aerobic conditions and obtain energy by oxidation of organic substances. Some representatives, for example yeasts, however, are facultative anaerobes and capable of obtaining energy by fermentation processes.
Dermatomycoses are diseases in which certain fungal species, in particular Dermatophytes, penetrate into the skin and hair follicles. T
Christophers Enno
Hoppe Udo
Schröder Jens-M
Wolf Florian
Beiersdorf AG
Norris & McLaughlin & Marcus
Russel Jeffrey E.
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