Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1991-11-08
1993-12-07
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424401, 424 59, 424 63, 424 65, 424 70, 424DIG4, 424DIG13, 4284022, 514827, 514852, 514864, A61K 9127
Patent
active
052681807
ABSTRACT:
This composition consists in an aqueous dispersion D, lamellar structure lipid vesicles encapsulating an aqueous phase E; it is characterised by the fact that the lipid phase forming the layers of the said vesicles is at least partly made up of a compound as formula (I): ##STR1## wherein R represents a linear saturated on unsaturated hydrocarbonated chain containing 9 to 17 carbon atoms. The compounds (I) have the advantage that they are easily biodegradable and of very low cytotoxicity.
REFERENCES:
Kiwada Chem. Pharm. Bull 33(2) 753, 1985.
Schenk et al, "Studies on sucrose-palmitate-stearate-containing vesicles encapsulating the cytostatic drug methylglyoxal-bis-quanyl-hydra-zone", Die Pharmazie, vol. 45, No. 10, Oct. 1990, pp. 747-749.
Derwent File Supplier WPIL (L), 1986 AN=86-282499.
Derwent File Supplier WPIL (L), 1989 AN=89-073938.
Kiwada et al, "Application of synthetic alkyl glycoside vesicles as drug carrier. I. Preparation and physical properties".
French Search Report of FR 90 13917.
Morancais Jean-Luc
Philippe Michel
"L'Oreal"
Kishore G. S.
Page Thurman K.
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