Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1994-07-15
1996-04-09
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 74, 4241951, A61K 742
Patent
active
055059341
DESCRIPTION:
BRIEF SUMMARY
This application is (the National Phase) of the PCT/FR91/00706, filed on Sep. 4, 1991.
The present invention relates essentially to a cosmetic or pharmaceutical composition, especially dermatological composition, containing an extract of Coleus esquirolii, Coleus scutellarioides or Coleus xanthanthus, intended in particular for promoting the pigmentation of the skin or hair, and to the process for its preparation.
It further relates to the use of an extract of Coleus esquirolii, Coleus scutellarioides or Coleus xanthanthus for the preparation of such a cosmetic or pharmaceutical composition.
The Coleus species belong to the family of the Labiatae, as do the very closely related Plectranthus species, and are often confused with one another since they generally also originate from the same regions. Thus the species Coleus barbatus is generally designated by the name Plectranthus barbatus, and the species Coleus aromaticus has the alternative name Plectranthus aromaticus. There are nearly 200 species of Coleus in existence, spread throughout the tropical and subtropical regions of Asia, Africa, Australia and the Pacific islands. About 9 species are indexed in India. The 10 principal varieties of Coleus are indexed in the Indian dictionaries, in particular "The Wealth of India, a Dictionary of Indian Raw Materials and Industrial Products, Raw Materials", volume II, Delhi 1950, pages 308-309; the book entitled "Indian Materia Medica" by Doctor K. M. Nadkarni's, third edition revised and enlarged by A. K. Nadkarni in two volumes, volume I, page 372; and the book entitled "The Flora of British India" by Sir J. D. Hooker, C. B., K. C., S. I., volume IV entitled "Asclepiadae to Amarantaceae", pages 624 to 627.
The use of Coleus forskholii as a raw material for the extraction of forskolin is already known, especially from the document FR-A-2 336 138. Forskolin is also known to have a slimming activity from a publication by GREENWAY in EP 190 165.
The documents FR-A-2 336 138 and EP-A1-0 243 646 also describe a number of pharmacological properties of these substances, such as a hypotensive and calming activity on the central nervous system.
The present invention is based on the discovery that extracts of Coleus esquirolii, Coleus scutellarioides or Coleus xanthanthus, although not containing forskolin, have valuable biological properties which can be used in the cosmetic and pharmaceutical fields. In particular, the inventors have observed that these extracts unexpectedly possess a melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles, and thus make it possible to promote the pigmentation of the skin or hair as well as to treat pigmentation disorders of the skin and hair, more particularly by promoting the biosynthesis of melanin.
One object of the present invention is therefore to solve the new technical problem which consists in providing a novel cosmetic or pharmaceutical composition, especially dermatological composition, intended in particular for promoting the pigmentation of the skin or hair.
A further object of the present invention is to solve the new technical problem which consists in preparing a novel formulation of a cosmetic or pharmaceutical composition having a good melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles.
A further object of the present invention is to provide a solution to the new technical problem which consists in providing a particularly easily obtainable plant extract which in itself has a good melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles, without having to isolate an active substance of any kind, these isolation processes generally being lengthy and expensive.
All these new technical problems are solved for the first time by the present invention in a satisfactory manner which can be used on the industrial scale.
Thus, according to a first feature, the present invention relates to a cosmetic or pharmaceutical composition, especially dermatological
REFERENCES:
patent: 4088659 (1978-05-01), Bhat
patent: 4453941 (1984-06-01), Jacobs
patent: 4931066 (1990-06-01), Grollier
patent: 5017368 (1991-05-01), Sugiyama
patent: 5078989 (1992-01-01), Ando
Bonte Frederic
Dumas Marc
Meybeck Alain
Huang Evelyn
Ivy C. Warren
L.V.M.H. Recherche
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