Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1993-12-06
1997-04-29
Gitomer, Ralph J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424423, 424450, 514783, 514844, 514845, 514846, 514847, 514859, 514860, 514861, 514863, 514886, 514887, A61K 3578, A61K 4700
Patent
active
056246730
DESCRIPTION:
BRIEF SUMMARY
The present invention relates essentially to a cosmetic or pharmaceutical composition, especially dermatological composition, containing an extract of prunella.
More precisely, the present invention relates to the use of an extract of prunella or at least one prunella saponin for the preparation of a cosmetic or pharmaceutical composition, especially dermatological composition, having in particular an anti-inflammatory, anti-allergic or anti-aging activity, promoting or regulating the renewal of skin cells, for preventing and treating hair loss or alopecia, and to a cosmetic composition for the application thereof.
The plants of the genus Prunella, in particular Prunella vulgaris L or "milfoil" also known as common prunella or comfrey, are common Labiatae in countries of the temperate zone, especially France. Conventionally, it was used fresh, with its sap, especially in the form of a gargle for treating sore throats and coughs.
It has also been used as an infusion to treat hemorrhages and diseases of the digestive tract. An antimutagenic activity of extracts of Prunella vulgaris L. has been described more recently by Lee and Lin in Mutation Research, 204 (1988), 229-234.
It is known that the effects of aging on the skin are characterized in particular by a slowing-down of the cell differentiation in the skin, resulting in a slowing-down of the renewal of the cells, their activity and their morphology, and a slowing-down of the transformation of the keratinocytes to corneocytes, giving the skin a duller, dried and more wrinkled appearance. Ageing also has adverse effects on the hair follicles. The cells of the follicles, like those of the epidermis, have their activity reduced by said effects, resulting in a slowing-down of the growth of the hair and, ultimately, degeneration of the follicle and the definitive loss of the hair.
One main object of the present invention is therefore to solve the novel technical problem which consists in providing a novel formulation of a cosmetic or pharmaceutical composition, especially dermatological composition, having a good efficacy in renewing the epidermis, renewing hair growth and preventing or slowing down hair loss, and in combating the effects of ageing on the condition of the skin, hair and nails.
A further main object of the present invention is to solve the novel technical problem which consists in providing a novel formulation of a cosmetic or pharmaceutical and/or dermatological composition having an anti-inflammatory activity, in particular on the erythema caused by ultraviolet radiation.
A further main object of the present invention is to solve the novel technical problem which consists in providing a novel formulation of a cosmetic or pharmaceutical composition, especially dermatological composition, having an anti-allergic activity.
A further main object of the present invention is to solve the above-mentioned novel technical problems in a particularly simple manner which does not necessarily require the isolation of a particular active substance or its synthesis, which is satisfactory and which can be used on the industrial scale.
Thus, according to a first feature, the present invention relates to the use of an extract of prunella or at least one prunella saponin for the preparation of a cosmetic or pharmaceutical composition, especially dermatological composition, regulating the renewal and differentiation of the keratinocytes, said composition having an anti-inflammatory activity, especially in inflammations caused by ultraviolet radiation, or an anti-allergic or anti-free-radical activity, for improving the functional condition of the skin or keeping it in a good functional condition, for preventing or treating dry skin, especially ichthyotic skin, and for treating psoriasis.
In one particularly preferred variant, the. above-mentioned prunella is Prunella vulgaris L. or common prunella.
In one particular variant, the above-mentioned extract of prunella or the above-mentioned prunella saponin is obtained by extraction from the whole plant or, prefera
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Bonte Frederic
Dumas Marc
Meybeck Alain
Gitomer Ralph J.
Lee Howard C.
LYMH Recherche
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