Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1994-10-19
1997-11-11
Venkat, Ph.D., Jyothsan
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424450, 4241951, 514844, 514846, A61K 748
Patent
active
056860820
DESCRIPTION:
BRIEF SUMMARY
The subject of the invention is a cosmetic or pharmaceutical composition containing, as antioxidizing agent, a combination, possessing a synergistic action, of a ginkgo extract and at least one polyphenol derivative.
The majority of cosmetic or pharmaceutic compositions consists of a fatty phase, the oily products of which have a certain tendency to oxidize, even at room temperature. This oxidation has the consequence of profoundly modifying the properties, especially olfactive, which makes them unusable after a variable period of time.
In order to protect the compositions with respect to these oxidation phenomena, it is common practice to incorporate protective agents which act as antioxidizing agents.
While antioxidizing agents are particularly useful for the good preservation of fats in cosmetic or pharmaceutical compositions, it is now known that some of them also make it possible to control the harmful effects of oxidizing substances, formed under the action of free radicals generated especially by atmospheric pollutants and ultraviolet radiation. These harmful effects are exerted in particular on the cells of the skin and of the mucous membranes in contact with the external environment.
It is thus important to be able to have available antioxidizing agents capable of inhibiting formation of free radicals and which make it possible to control oxidation phenomena which can cause irreversible cell damage.
It has now been discovered that it was possible both to obtain good preservation of cosmetic or pharmaceutical compositions containing easily oxidizable fats and to efficiently protect the skin or the mucous membranes by using a combination of a ginkgo extract and at least one polyphenol compound. It has additionally been discovered that this combination surprisingly possesses synergistic properties.
The expression "polyphenol compound" is understood to mean compounds containing at least one diphenol aromatic ring, it being possible for the phenol groups to be optionally etherified or esterified. In what follows, such a compound can also be called simply "polyphenol".
The subject of the invention is thus a cosmetic or pharmaceutical composition containing an antioxidizing system possessing a synergistic action consisting of the combination of a ginkgo extract and at least one polyphenol compound.
The active substance (or the active substances) of the ginkgo extract is not known but this active substance can be obtained by extracting the plant matter, and especially the leaves, using a nonpolar solvent. The expression "nonpolar extract" hereinafter denotes either such an extract or one or more active substances contained in such an extract and which can be isolated therefrom by a more exhaustive purification. An active substance here denotes a substance having an antioxidizing activity (which can be revealed, for example, according to a self-oxidation test of vitamin F as described in the experimental part below) and whose combination with a polyphenol makes it possible to reveal a synergistic antioxidizing action.
An extract from Ginkgo biloba leaves is especially used.
The nonpolar ginkgo extract can be obtained by evaporating to dryness fractions resulting from extraction of ginkgo leaves with a nonpolar solvent. Linear, branched or cyclic C.sub.6 -C.sub.14 alkanes may be mentioned as nonpolar solvent, n-hexane being particularly preferred. Such extracts are described especially in Japanese Patent 91-014,007.
The polyphenol compounds used in the composition of the invention can be chosen from those which have an antioxidizing activity in a self-oxidation test of vitamin F as described below in the experimental part.
The polyphenol can be chosen, for example, from: (2,5-dihydroxyphenyl)alkylenecarboxylic acids and their derivatives, especially their salts, esters or amides,
Mention will be made, among the polyphenols which can be used, of especially flavonoids corresponding to the general formula (I): ##STR1## or (II): ##STR2## in which A", B", C" and D", independently of one another, represent H or O
REFERENCES:
patent: 4289495 (1981-09-01), Bugaut et al.
patent: 5043323 (1991-08-01), Bombardelli et al.
patent: 5114716 (1992-05-01), N'Guyen et al.
Morelle, "Que peuvent nous apported les extraits vegetaux?: Le ginkgo biloba", Parfums, Cosmetiques et Aromes, vol. 96, 1991, pp. 77-86.
Matsui, "Manufacture of extract with high content of flavonoids from gingko leaves", Chemical Abstracts, vol. 116 No. 4, 1992, Abstract No. 28119h.
"L'Oreal"
Venkat, Ph.D. Jyothsan
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