Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1994-05-27
1996-05-07
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424 63, 424 706, 424 7803, 514558, A61K 3578, A61K 7021
Patent
active
055143741
DESCRIPTION:
BRIEF SUMMARY
The present invention relates essentially to a cosmetic or pharmaceutical composition, especially dermatological composition, containing an extract of black horehound, intended in particular for promoting the pigmentation of the skin or hair or for reducing the amount of triglycerides in the adipocytes, and to the process for its manufacture.
The present invention further relates to the use of an extract of black horehound for the preparation of such a cosmetic or pharmaceutical composition intended in particular for treating pigmentation disorders or for reducing the amount of triglycerides in the adipocytes.
The plants of the genus Ballota belong to the family of the Labiatae, which are found in temperate regions. An example which may be mentioned is Ballota nigra (LINN.) or Ballota foetida, also known as black horehound. This is a common perennial plant which is found particularly in uncultivated places, along hedges, paths or walls. It has a most unpleasant smell. Other examples which may be mentioned are Ballota lanata, which is cultivated in gardens, and Ballota suavelens or odoriferous ballota, which is recommended as an emmenagogue and antihysteric.
Black horehound is traditionally said to possess tonic, stomachic, antispasmodic, calming, depurative, diuretic, anthelmintic, resolvent and detersive properties.
The present invention is based on the discovery that extracts of black horehound originating from the whole plant, and especially from the aerial parts and in particular the stems and leaves, have valuable biological properties which can be used in the fields of 05 cosmetics and pharmaceutics. The inventors have observed in particular that these extracts unexpectedly possess a melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles, especially those on the scalp, and thus make it possible to promote the pigmentation of the skin or hair and to treat pigmentation disorders of the skin and hair by promoting more particularly the biosynthesis of melanin. Very good results in this field have been obtained with extracts of the whole plant, and especially of the aerial parts and in particular the stems and leaves of black horehound.
The inventors have also observed that the abovementioned extracts of black horehound are unexpectedly active in reducing the amount of triglycerides in the adipocytes, especially by inhibiting their synthesis in these cells. These extracts thus make it possible to prevent the development of accumulations of fat in the organism, such as cellulitis, so they are particularly useful for the preparation of cosmetic or pharmaceutical slimming compositions, especially dermatological slimming compositions.
One object of the present invention is therefore to solve the new technical problem which consists in providing a novel cosmetic or pharmaceutical composition, especially dermatological composition, intended in particular for promoting the pigmentation of the skin and for preventing or slowing down the appearance of white hair.
A further object of the present invention is to solve the new technical problem which consists in preparing a novel formulation of a cosmetic or pharmaceutical composition which has a good melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles, especially those on the scalp.
A further object of the present invention is to provide a solution to the new technical problem which consists in providing a particularly easily obtainable plant extract which in itself has a good melanogenesis-stimulating activity on the melanocytes present in the skin or the hair follicles, without it being necessary to isolate an active substance of any kind, these isolation processes generally being lengthy and expensive.
A further object of the present invention is to solve the new technical problem which consists in preparing a novel formulation of a cosmetic or pharmaceutical composition which is active in reducing the amount of triglycerides in the adipocytes, thereby making it possible to preve
REFERENCES:
Chem. Absts. 91(11)91790a, 1979.
Bonte Frederic
Dumas Marc
Meybeck Alain
L.V.M.H. Recherche
Rollins John W.
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