Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1993-10-26
1997-05-13
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424 701, 424 704, 424 705, A61K 706
Patent
active
056290020
DESCRIPTION:
BRIEF SUMMARY
The invention relates to cosmetic or pharmaceutic preparations for improving the quality of the hair and stimulating the growth of the hair, which preparations are based on alkali metal, alkaline earth metal and/or ammonium salts of thiocyanic acid, and to the use thereof.
From EP-0 336 236 A2 there has been known the application to man of physiologic salts of thiocyanic acid as a cosmetic agent for hair care, for maintaining and stimulating the growth of the hair and for increasing the resistance of the hair to harmful or noxious influences. According thereto, the salts of thiocyanic acid are also applicable to useful animals for increasing the yield and improving the quality (shine, coat structure, hair strength and elasticity, denseness and uniformity of the coat of hair, softness and tenacity during the processing operations) in the wool, fur, leather and/or feather production. The application route to man is mainly topical (in cosmetic or pharmaceutic preparations, e.g. as an additive to the bath water, hair tonic, shampoo and hair packs), while the application route to the useful animal is mostly oral, by admixing thiocyanate preparations to the fodder or by employing thiocyanate-enriched fodder.
It has further been known that placenta and its ingredients, e.g. estrogens and other hormones as well as allantoin, sulfur, disulfides, selenium, salts of heavy metals, antioxidants, vasodilators, vitamins, especially vitamin A, vitamins of the B group, in particular thiamine, vitamins of the D group, in particular vitamin D.sub.3, pantothenic acid and tocopherol, amino acids, peptides, proteins or protein hydrolyzates, carboxylic acids, microbial, vegetable and animal extracts or extracts from human tissue, e.g. placenta, as well as natural and/or artificially generated UV radiation, also in combination with photosensitizers, can display a more or less stimulating influence on the growth of the hair. However, the effects achieved thereby, as a rule, are not significant and not reproducible in practice. In addition, a number of said active ingredients involves the danger of producing acute and chronic side-effects which would exclude any long-term application.
In the DE-PS 30 39 281 it is determined that the obviously noxious influence of SCN.sup.- caused by the use of raw materials of vegetable origin can be compensated only by using suitable compensating agents such as, e.g., copper(II) ions. Moreover, from said printed publication it is derivable that the amounts to be employed of SCN.sup.- are to be minimized to the lowest possible extent because of the obviously toxic effect. A restriction of the contents of Cu.sup.2+ to from 1.5 to 6 mg/l and of SCN.sup.- to from 1 to 5 mg/l was provided for toxicologic reasons. In the proposed mixture, the SCN.sup.- content decreases in response to external influencing factors onto the redox potential (e.g. atmospheric oxygen, dust) irregularly, but altogether continuously. Under this aspect, the claimed contents of Cu.sup.2+ and SCN.sup.- are not long term-stable biologically active and desirable additives. Nevertheless, at the same time there is only available a lower amount of SCN.sup.- due to the fast loss of free thiocyanate ions.
In EP-A-0 059 428 B1 EP-A0-059 428B1(AT-E-13-484) there has been described a hair treatment agent, in accordance with which cosmetic hair treatment agents comprising a protein hydrolyzate and alkali thiocyanates have been known, which agent imparts smoothness and softness to the hair and is reported to support an effective shaping without any undesirable tackiness. Any influence onto the growth of the hair (maintenance and stimulation) and the hair quality, such as increasing the resistance to harmful influences, has not been disclosed.
From DE 33 38 339 A1 there have been known active substances exhibiting a progesterone-like activity to reduce the dihydrotestosterone plasma level as agents for combatting alopecia of males.
It has been known that disorders of hormonal incretion may impair the healthy growth of hair. "This recognition
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Koch Stefan
Kramer Axel
Meffert Hans
Sima Dagmar
Tirsch Christel
Howard Sharon N.
Page Thurman K.
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