Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-07-02
2003-01-14
Travers, Russell (Department: 1619)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S401000, C424S400000, C424S070210, C514S557000, C514S558000, C514S937000, C514S938000, C514S941000, C514S943000
Reexamination Certificate
active
06506391
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a composition in the form of a dispersion of an oily phase and an aqueous phase, the dispersion being stabilized with cubic gel particles formed using a combination of two amphiphilic compounds, as well as to the use of the said composition, in particular in the cosmetic, dermatological and/or pharmaceutical fields, more particularly for the care and/or conditioning and/or hygiene and/or making up of the skin, mucous membranes, the scalp and/or the hair.
2. Discussion of the Background
A large variety of products have the form of a dispersion of an oily phase and of an aqueous phase. It is possible for the internal phase to be aqueous (water-in-oil or W/O emulsion) or oily (oil-in-water or O/W emulsion). This relates most particularly to cosmetic, dermatological or pharmaceutical topical products, in which dispersions give the skin good sensory properties. However, it is well known that these dispersions lack stability over time and “break”, giving rise to two separate phases which makes them unusable. In order to stabilize these dispersions, an emulsifier is usually added thereto; the nature and concentration of the emulsifier used can significantly influence the stability of such compositions. In addition, it is quite certain that the choice and concentration of a suitable emulsifier will depend on various factors, and in particular on the oil(s) constituting the oily phase of the dispersion or emulsion. Moreover, certain emulsifiers are not without drawbacks, in particular when they are used in high concentration in order to improve the stability of the dispersion. They can cause irritation, in particular on sensitive skin.
To overcome this drawback, document EP-A-711,540 has proposed stabilizing O/W dispersions with cubic gel particles. The term “cubic gel” denotes transparent gels, in the form of a cubic liquid crystal phase. which are isotropic in polarized light. The cubic phases are organized in a bipolar manner in separate hydrophilic and lipophilic domains, in close contact and forming a thermodynamically stable three-dimensional lattice. Such an organization has been described in particular in “La Recherche”, Vol. 23, pp 306-315, March 1992, and in “Lipid Technology”, Vol. 2, No. 2, pp. 42-45, April 1990. Depending on the arrangement of the hydrophilic and lipophilic domains, the cubic phase is said to be of normal or inverse type. The term “cubic gel” as used according to the present invention includes, of course, gels with different types of cubic phases. However, the technique described in document EP-A-711,540 has the drawback of allowing only O/W emulsions to be obtained.
Surprisingly, it has now beer found that both W/O and O/W stable dispersions or emulsions can be obtained using cubic gel particles, obtained from a mixture of two amphiphilic compounds which are capable of reacting in a different manner in the presence of water. For example, one of the amphiphilic compounds is capable of forming a lamellar phase and the other is capable of forming an inverse hexagonal phase.
SUMMARY OF THE INVENTION
A subject of the present invention is a composition in the form of a dispersion comprising an aqueous phase and an oily phase, characterized in that it also comprises cubic gel particles, formed by mixing together at least two amphiphilic compounds, one of the amphiphilic compounds being capable of forming a lamellar phase in the presence of water, and the other being capable of forming an inverse hexagonal phase in the presence of water.
The mixture of the two amphiphilic compounds forming the cubic gel particles is characterized in that neither of the two amphiphilic compounds can by itself lead to a cubic phase when it is placed in contact with water and that only their mixture leads to such a phase, and that, moreover, one of the amphiphilic compounds is capable of forming a lamellar phase in the presence of water, while the other amphiphilic compound is capable of forming an inverse hexagonal phase in the presence of water.
DETAILED DESCRIPTION OF THE INVENTION
The term “lamellar phase” (phase D according to Ekwall) means a liquid crystal phase with plane symmetry, comprising several amphiphilic bilayers arranged in parallel and separated by a liquid medium which is generally water.
The term “inverse hexagonal phase” (phase F according to Ekwall) means a liquid crystal phase corresponding to a hexagonal arrangement of parallel cylinders filled with a liquid medium which is generally water, separated by a hydrocarbon-based environment corresponding to the fatty chains of the amphiphile. A more precise description of these phases can be found in Revue Francaise des Corps Gras, No. 2, February 1969, pp. 87 to 111 (Lachampt et Vila, “Textures des phases paracristallines” [Textures of paracrystalline phases]), incorporated herein by reference.
The amphiphilic compound capable of forming a lamellar phase is preferably chosen from diglycerol monoesters, such as diglyceryl isostearate (Solvay) and diglyceryl monooleate (Rylo PG 29® sold by Danisco), alone or as a mixture.
The amphiphillic compound capable of forming an inverse hexagonal phase is preferably chosen from diglycerol mono-, di- or triesters, aminopolyol carbamates and mixtures thereof. Examples of diglycerol mon-, di- or triesters are diglyceryl 2-decyltetradecanoate and diglyceryl di-/trioleat (TSED 396® sold by Danisco). Examples of aminopolyol carbamates are 3-N-(2-decyltetradecyloxycarboxyl)amino-1,2-propanediol and N-2-dodecyldexadecyloxycarbonyl-N-methyl-D-glucamine. These aminopolyol carbamates are described in document U.S. Pat. No. 5,788,992, incorporated herein by reference.
The mixture of the two types of amphiphilic compound can contain 10, 20, 30, 40, 50, 60, 70, 80, or 90% of at least one amphiphilic compound capable of forming a lamellar phase, inclusive of all values and subranges therebetween. Preferably, the mixture consists of from 10 to 90% by weight and more preferably 15 to 85% by weight of at least one amphiphilic compound capable of forming a lamellar phase. The mixture can also contain 10, 20, 30, 40, 50, 60, 70, 80, or 90% of at least one amphiphilic compound capable of forming an inverse hexagonal phase, inclusive of all values and subranges therebetween. Preferably, the mixture contains from 10 to 90% by weight and more preferably from 15 to 85% by weight of at least one amphiphilic compound capable of forming an inverse hexagonal phase, relative to the total weight of the mixture.
The ratio between the two types of amphiphilic compound depends on the compounds used, and a person skilled in the art will know how to determine the amount of each type of compound to be used in order to obtain cubic gel particles. For example, the mixtures constituting the cubic gel particles of the compositions of the invention are preferably prepared using the following combinations:
55 to 75% by weight of diglyceryl isostearate and 25 to 45% by weight of diglyceryl 2-decyltetradecanoate;
30 to 65% by weight of diglyceryl isostearate and 35 to 70% by weight of diglyceryl di-/trioleate;
75 to 85% by weight of diglyceryl isostearate and 15 to 25% by weight of 3-N-(2-decyltetradecyloxycarbonyl)amino-1,2-propanediol;
55 to 75% by weight of diglyceryl isostearate and 25 to 45% by weight of N-2-dodecylhexadecyloxycarbonyl-N-methyl-D-glucamine;
15 to 50% by weight of diglyceryl monooleate and 50 to 85% by weight of diglyceryl di-/trioleate.
The composition can comprise 0.1, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15% of amphiphilic compounds constituting the particles of the cubic phase, inclusive of all values and subranges therebetween. The composition preferably comprises from 0.1 to 15% by weight and better still from 0.5 to 10% by weight of amphiphilic compounds constituting the particles of the cubic phase, relative to the total weight of the composition, and/or from 2 to 40% by weight of oily phase relative to the total weight of the composition.
The weight ratio of the amphiphilic compound
L'Oreal
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Sharareh S
Travers Russell
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