Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1998-08-18
2000-09-26
Levy, Neil S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424401, 424405, 424406, 424438, 424486, 424487, 424 768, 424 7818, 424 782, 424 7831, 424 59, 424 62, 424 63, 424 65, 424 69, 424 7805, 424 7806, 424 7807, 514738, 514944, A01N 2524
Patent
active
061239534
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Human or animal skin (that of mammals) is not sterile. It breeds either saprophyte germs which constitute the non-pathogenic and protective resident microflora, or parasitic pathogenic germs which are opportunistic, which can give rise to illness or more or less serious pathological conditions, especially if they succeed in penetrating tissue internally to colonize the blood or lymphatic system or internal organs.
Asepticizing treatment of human and/or animal skin seeks its origins in the work of Pasteur and Semmelweiss; nowadays, there exist a large number of microbicidal molecules used for different applications: treatment of acne, treatment of capillary layers, different disinfection of small wounds (scrapes), disinfection of the hands of surgeons and the sick, disinfection of the udders of milk-giving animals to prevent mastitis.
The antimicrobial properties of 1,2-diol alkanes and 1,3-diol alkanes are known from EP-A-0524548, which also mentions their combination with aromatic alcohol for the preservation of cleaning agents for the skin, but with a decrease of germs only after several days.
The bacteriostatic effect of the compounds of the formula R-CHOH-CH.sub.2 OH on gram positive bacteria and mold, is known from JP-A-51 091 327 for application to food products and seeds, or other industrial products.
SUMMARY OF THE INVENTION
The object of the present patent application is the discovery that the class of molecules of the general formula:
in which R is a straighter branch chain alkyl of 3 to 12 carbon atoms, preferably straight chain of 6 to 8 carbon atoms, has a sufficiently strong microbicidal activity to be usable in treatments of the skin mentioned above. These alkane-diol molecules have been described as hydrating ingredients, as antimicrobial preservatives for the protection of cosmetic products; their topical use on the skin to fight pathogenic microbes has not been envisaged.
Moreover, it has been discovered that the combination of the alkane-diols with gels of the glyceryl polymethacrylate type, in a formula, is even more effective than each of the components alone.
French patent FR 2682296 has proposed a method of non-chemical preservation of cosmetic products or dermopharmaceuticals which is based on the use of gels of the glyceryl polymethacrylate type, whose property is to exert a strong osmotic influence on their environment, which permits inactivating the microorganisms introduced into a cosmetic preparation by depriving them of water. French patent 2.737.406 has proposed an improvement in the effectiveness of the method by associating polyols and a fluidizing agent for the polymethacrylate gel.
The object of the present patent application is that alkane-diols can be used in combination with the mentioned gels, at low concentrations, for the treatment of the problems of acne, skin troubles, impetigo, body odors caused by microorganisms, athlete's foot and other mycoses, microbial cutaneous afflictions in general, and the prevention of mastitis by topical application.
A gel of glyceryl polymethacrylate like those described in French patent 2682296 or 2678830, which inactivates the microorganisms introduced into a cosmetic preparation by depriving them of water, loses its activity when it is too dilute. However, when there is added an alkane-diol of formula (I), even at low concentration, there is noted an effect of inactivation of the germs, which is rapid and much stronger than the addition of the two substances would cause one to suppose. There is thus a synergy between the gel, with its osmotic power, and the alkane-diol, and its antimicrobial effect.
This is even more important because it permits decreasing the concentrations of diol necessary to obtain a microbicidal activity in the final products. The short chain alkane-diols can have slightly irritating properties, the usable concentration without risk is thus limited. The synergy with the gel permits overcoming this obstacle.
The gel of the glyceryl polyacrylate or polymethacrylate type is particu
Levy Neil S.
STOA S.A.
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