Cosmetic compositions containing resveratrol and retinoids

Details Cosmetic compositions containing resveratrol and retinoids Cosmetic compositions containing resveratrol and retinoids

2000-09-18

2002-03-19

Dudash, Diana (Department: 1619)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

C424S448000, C424S616000, C424S058000

Reexamination Certificate

active

06358517

ABSTRACT:

FIELD OF THE INVENTION
Cosmetic compositions containing resveratrol in combination with retinoids and methods of conditioning skin by applying such compositions to the skin.
BACKGROUND OF THE INVENTION
Estrogens and synthetic compounds which act like estrogens are known to increase the thickness of the dermal layer and reduce wrinkle formation in the aging skin. Changes in the skin such as skin dryness, loss of skin elasticity and plumpness occurring after menopause are attributed to the lack of estrogen production. Estrogen therapy prevents or slows down many of the changes associated with aging skin (Creidi et al., Effect of a conjugated oestrogen cream (Premarin®) on aging facial skin, Maturitas, 19, p.211-23, 1994). Natural estrogen, estradiol, has the following structure:
Retinol (vitamin A) is an endogenous compound which occurs naturally in the human body and is essential for normal epithelial cell differentiation. Natural and synthetic vitamin A derivatives have been used extensively in the treatment of a variety of skin disorders and as skin repair and renewal agents. Retinoic acid has been used to treat a variety of skin conditions such as acne, wrinkles, psoriasis, age spots and skin discoloration.
Estradiol induces the expression of retinoid receptors in 2 different cell types. In mouse cervical epithelial cells estradiol stimulates the expression of retinoid X receptors and retinoic acid receptors (Exp Cell Res., 226: 273, 1996). In breast cancer cells estradiol induces the expression of a subtype of retinoic acid receptor gene expression (Mol. Endocrinol. 12: 882, 1998). Human skin expresses large amounts of the same types of retinoic acid receptors and retinoid X receptors (Voorhees et al, skin pharmacol., 6:70, 1993). However, unlike breast or cervix, skin is not a target organ for estrogen action.
Ptchelintsev et al. (U.S. Pat. Nos. 5,847,003 and 5,834,513) disclose compositions containing oxaacids and related compounds and which may further include numerous optional ingredients, among which are mentioned estradiol, retinoids and bioflavonoids.
The consumer demand for products containing plant extracts or ingredients derived from plants has been growing in recent years. Such products are perceived by consumers as pure and mild and superior to chemically synthesized products.
Phytoestrogens are natural compounds which have estrogen-like activity and which are found in plants. Some bioflavonoids, such as genistein and daidzein, are known phytoestrogens. WO 99/04747 (Unilever) teaches that resveratrol, a compound found in a variety of plants, is a phytoestrogen and discloses cosmetic compositions containing resveratrol. One of the disclosed compositions also includes retinyl palmitate.
The present invention is based in part on the discovery that not all phytoestrogens and not all retinoids exhibit synergy when combined. The combination of resveratrol with selected retinoids, however, synergistically enhanced the beneficial effects of retinoids on skin.
The art discussed above does not describe the presently claimed combinations of resveratrol and retinoids for skin care cosmetic use.
SUMMARY OF THE INVENTION
The present invention includes a cosmetic skin care composition comprising resveratrol in an amount of from 0.00001 to 10 wt. %, a retinoid selected from the group consisting of retinoic acid, retinol, retinyl acetate and retinyl linoleate, and a cosmetically acceptable vehicle.
The present invention also includes a method of improving or preventing the condition of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility, radiance, glow and plumpness, which method includes applying to the skin the inventive composition. Compositions of the invention are intended for topical application to mammalian skin which is already dry, flaky, lined, wrinkled, aged, photodamaged, or the inventive compositions may be applied prophylactically to reduce the deteriorative changes.
DETAILED DESCRIPTION OF THE INVENTION
Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word “about.” All amounts are by weight of the composition, unless otherwise specified.
Resveratrol (also known as 5-parahydroxystyryl resorcinol, or 3,4′5-stilbenetriol) is an essential ingredient of the inventive composition. Resveratrol has the following structure:
Pure resveratrol may be obtained commercially from Sigma, and in crude form from other cosmetic suppliers such as DNP International, Pharma Science or Madis Botanicals.
In general, the amount of resveratrol in the inventive compositions is in the range of from 0.00001 to 10% by weight composition. Preferably in order to lower cost and maximize the effect the amount of resveratrol is in the range of from 0.001% to 5% and most preferably is in the range of from 0.1% to 5%.
The inventive compositions further comprise a retinoid selected from the group consisting of retinoic acid, retinol, retinyl acetate, and retinyl linoleate. It has been found that these retinoids, but not retinyl palmitate, act synergistically in combination with resveratrol.
Most preferred retinoid is selected from retinol, retinyl acetate and retinyl linoleate, because of its proven cosmetic efficacy.
The retinoid is generally employed in the inventive compositions in an amount of from 0.001 to 10%, preferably from 0.01 to 1, most preferably from 0.01 to 0.5% by weight of the compositions.
The composition according to the invention also comprises a cosmetically acceptable vehicle to act as a diluant, dispersant or carrier for resveratrol and the reinoid in the composition, so as to facilitate their distribution when the composition is applied to the skin.
Vehicles other than or in addition to water can include liquid or solid emollients, solvents, humectants, thickeners and powders. An especially preferred nonaqueous carrier is a polydimethyl siloxane and/or a polydimethyl phenyl siloxane. Silicones of this invention may be those with viscosities ranging anywhere from about 10 to 10,000,000 mm
2
/s(centistokes) at 25° C. Especially desirable are mixtures of low and high viscosity silicones. These silicones are available from the General Electric Company under trademarks Vicasil, SE and SF and from the Dow Corning Company under the 200 and 550 Series. Amounts of silicone which can be utilized in the compositions of this invention range anywhere from 5% to 95%, preferably from 25% to 90% by weight of the composition.
The cosmetically acceptable vehicle will usually form from 5% to 99.9%, preferably from 25% to 80% by weight of the composition, and can, in the absence of other cosmetic adjuncts, form the balance of the composition. Preferably, the vehicle is at least 80 wt. % water, by weight of the vehicle. Preferably, water comprises at least 50 wt. % of the inventive composition, most preferably from 60 to 80 wt. %, by weight of the composition.
Optional Skin Benefit Materials and Cosmetic Adjuncts
An oil or oily material may be present, together with an emulsifier to provide either a water-in-oil emulsion or an oil-in-water emulsion, depending largely on the average hydrophilic-lipophilic balance (HLB) of the emulsifier employed.
The inventive compositions preferably include sunscreens. Sunscreens include those materials commonly employed to block ultraviolet light. Illustrative compounds are the derivatives of PABA, cinnamate and salicylate. For example, octyl methoxycinnamate and 2-hydroxy-4-methoxy benzophenone (also known as oxybenzone) can be used. Octyl methoxycinnamate and 2-hydroxy-4-methoxy benzophenone are commercially available under the trademarks, Parsol MCX and Benzophenone-3, respectively. The exact amount of sunscreen employed in the emulsions can vary depending upon the degree of protection desired from the sun's UV radiation.
Emollients are often incorporated into cosmetic compositions of the present invention

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