Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1993-12-23
1996-05-21
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424401, 424 7013, 514 53, 514 54, 514 61, A61K 606, A61K 700
Patent
active
055187331
DESCRIPTION:
BRIEF SUMMARY
The invention relates to cosmetic compositions containing oligosaccharides.
Man and animals are host to populations of microorganisms which develop naturally both at the surface and in the cavities of their bodies. These microbial flora, or endogenous microflora, are characteristic of the species and of the region of the body where they develop. In close contact with their host, certain microorganisms are known to have a beneficial action on the skin or vaginal mucous membrane, for example by maintaining a slightly acidic environment and/or by participating in the protection of the organism against infections by pathogenic microorganisms which are present in small numbers or which are not usually present on the skin or on the vaginal mucous membrane.
It would therefore be useful to have available cosmetics which create a medium favorable for the development of the beneficial endogenous flora and which orient the metabolism of the whole endogenous microflora such that the said microflora participates in maintaining the good physico-chemical balance of the skin and the mucous membranes while not concomitantly favoring the development of pathogenic microorganisms.
During extensive research studies, the Applicant has found that certain oligosaccharides constitute products which can be easily metabolized by several beneficial strains of the skin microflora and of the vaginal flora. A substantial gluco-oligosaccharide metabolism by non-pathogenic strains such as Micrococcus kristinae, Micrococcus sedentarius, Staphylococcus capitis, Corynebacterium xerosis and Lactobacillus pentosus has thus been observed during in vitro culture studies. On the other hand, pathogenic or opportunistic strains such as Staphylococcus aureus, Gardnerella vaginalis and Propionibacterium acnes do not metabolize, or very slightly metabolize these oligosaccharides.
Furthermore, it has also been observed that, in the presence of these oligosaccharides, certain strains such as Lactobacillus pentosus, Micrococcus kristinae, Gardnerella vaginalis, Propionibacterium avidum and Propionibacterium granulosum, acidify the culture medium. Lactobacilli produce in particular lactic acid.
The invention therefore relates to cosmetic compositions, characterized in that they comprise at least one oligosaccharide chosen from the group consisting of gluco-oligosaccharides, fructo-oligosaccharides, .alpha.- and .beta.-galacto-oligosaccharides and mixtures thereof.
Glucosaccharides which can be used in the cosmetic compositions of the invention are especially gluco-oligosaccharides corresponding to the general formula: isomaltose, isomaltotriose, methyl .alpha.-glucoside and glucose, and n=1 to 10, the glucoside bonds being of the .alpha.(1.fwdarw.6) and, optionally, .alpha.(1.fwdarw.2) and/or .alpha.(1.fwdarw.3) type, the .alpha.(1.fwdarw.2) bond, if present, being situated at the non-reducing end or constituting a branch point.
The above oligosaccharides can be produced by known processes for enzymatic synthesis by means of the enzyme glucosyl-transferase derived from the bacteria Leuconostoc mesenteroides, in the presence of sucrose and a glucose-accepting sugar chosen from maltose, isomaltose, isomaltotriose, methyl .alpha.-glucoside and glucose.
Such processes are described in the literature, for example in EP-A-0,325,872, by Paul et al. in Carbohydrate Research, 149 (1986), pages 433-441 and in U.S. Pat. No. 2,726,190. Strains of Leuconostoc mesenteroides which are preferred for the implementation of the process of synthesis are the strains NRRL B-512(F) (for the production of gluco-oligosaccharides with only .alpha.(1.fwdarw.6) bonds) and NRRL B-1299 (for the production of gluco-oligosaccharides with .alpha.(1.fwdarw.6) and .alpha.(1.fwdarw.2) bonds).
Maltose is most particularly preferred as glucose-accepting sugar.
Useful fructo-oligosaccharides, separately or in the form of a mixture, are especially those corresponding to the general formula GFn or to the general formula Fm where G is a glucose residue, F a fructose residue and n equals 1 to 10,
REFERENCES:
patent: 2726190 (1955-12-01), Koepsell
patent: 3894146 (1975-07-01), Tsuyama
patent: 4340673 (1982-06-01), Stoudt
patent: 4364837 (1982-12-01), Pader
patent: 4435389 (1984-03-01), Mutai
patent: 4518581 (1985-05-01), Miyake
patent: 4812444 (1989-03-01), Mitsuhashi et al.
patent: 4987124 (1991-01-01), Speights
patent: 5087449 (1992-02-01), Masai
patent: 5164183 (1992-11-01), Komoda
Lamothe Jean-Pierre H. G.
Marchenay Yves G.
Monsan Pierre F.
Paul Francois M. B.
Pelenc Vincent
BioEurope
Gardner Sally
Page Thurman K.
LandOfFree
Cosmetic compositions containing oligosaccharides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cosmetic compositions containing oligosaccharides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cosmetic compositions containing oligosaccharides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2036055