Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1989-12-15
1992-01-28
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
514625, A61K 742, A61K 3116
Patent
active
050842706
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to N-alkoxyalkylamides and to the use of such compounds in cosmetic compositions, including compositions and processes for providing moisturizing and/or softening properties to human skin, particularly common or mild to moderate "dry skin". The invention will be described initially in connection with its use to treat dry skin conditions. However, as described hereafter, the cosmetic composition of the present invention can be used advantageously for other types of cosmetic applications.
The human skin disorder known as "dry skin" is characterized by cracking, flaking or scaling of the skin of the hands, feet, neck, face or other parts of the body. This disorder may result from a hereditary disorder known as ichthyosis which is a severe form of dry skin. This form of dry skin is not too prevalent. The more common form of "dry skin," which affects a relatively large portion of the population, is a mild to moderate form of dryskin which arises due to exposure to environmental conditions of low humidity in the fall and winter seasons of the temperate climate zones. These environmental conditions give rise to, in skin areas exposed thereto, a loss of moisture from such skin areas, with the attendant formation of fissures, chaps, cracks or flakes in such affected skin areas.
REPORTED DEVELOPMENTS
Various chemical compounds have been proposed for use in combatting such dry skin problems. These compounds are normally formulated with other materials so as to be useful for topical application to the skin in the form of a lotion, cream or ointment.
Examples of such prior art compounds, and the topical compositions in which they may be used for treating dry skin, are disclosed, for example, in U.S. Pat. Nos. 3,230,228; 3,322,635; 4,105,783, 4,197,316; 4,382,765 and W. German OLS 2,632,391. The compounds of these references include some hydroxy-containing carboxylic acid amides.
OBJECTS OF THE PRESENT INVENTION
An object of the present invention is to provide novel compounds useful for the treatment of the mild to moderate form of dry skin.
A further object of the present invention is to provide novel cosmetic compositions based on N-alkoxyalkylamides, including the novel compounds of the present invention and/or known compounds which are useful for a variety of cosmetic purposes, including the treatment of mild to moderate dry skin.
SUMMARY OF THE PRESENT INVENTION
It has now been found that these and other objects of the present invention may be accomplished by the use, for dry skin treating and other cosmetic purposes, of N-alkoxyalkylamides as described below.
Accordingly, one aspect of the present invention comprises a cosmetic composition having, as one of its essential constituents, one or more N-alkoxyalkylamides of the general formula ##STR1## wherein p is a whole number from 1 to about 4, (C.sub.n H.sub.2n) is a straight or branched chain alkyl bridge in which n is a whole number of 1 to about 6, and is preferably 3, and which m is a whole number of 1 to about 6, and is preferably 1.
For convenience, compounds within the scope of Formula I above are hereafter sometimes referred to as "alkoxyamides". The cosmetic composition of the present invention includes also as an essential constituent a material, hereafter referred to as "a carrier," which is effective in providing the alkoxyamide-containing composition in a form such that the composition can be applied to external portions of the body, for example, the skin.
Another aspect of the present invention comprises novel N-alkoxyalkylamide compounds having the general formula ##STR2## wherein p is a whole number from 1 to 4, (C.sub.n H.sub.2n) is a straight or branched chain alkyl bridge in which n is a whole number of 1 to 4, and is preferably 3, and which m is a whole number of 1 to 4, and is preferably 1.
The most preferred amide compound of Formula II above is that wherein p is 4, n is 3 and m is 1. Such compound is methoxy propyl gluconamide also referred to hereafter as "MPG", ##STR3## The par
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Blackburn Julie
Revlon Inc.
Schenkman Leonard
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