Cosmetic compositions containing lactate dehydrogenase inhibitor

Details Cosmetic compositions containing lactate dehydrogenase inhibitor Cosmetic compositions containing lactate dehydrogenase inhibitor

1994-12-20

1997-11-25

Marquis, Melvyn I.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514784, A61K 600

Patent

active

056909446

ABSTRACT:
Inhibitors of lactate dehydrogenase stimulate keratinocyte proliferation and collagen synthesis in cutaneous tissues. The inhibitors are used preferably with certain co-active ingredients such as pyruvic acid, acetic acid, acetoacetic acid, .beta.-hydroxybutyric acid, a Krebs cycle pathway metabolite, an aliphatic saturated or an unsaturated fatty acid containing from 8 to 26 carbon atoms, an .omega.-hydroxy acid containing from 22 to 34 carbon atoms, glutamic acid, glutamine, valine, alanine, leucine, and mixtures thereof.

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Rohde et al., "Contact Lens-Induced Edema In-Vitro Amelioration by Lactate Dehydrogenase Inhibitors", Curr Eye Res, vol. 5, No. 10, issued Oct. 1986, pp. 751-758.
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Linnane, Anthony W., et al., "Mitochondrial DNA Mutation and the Ageing Process: Bioenergy and Pharmacological Intervention", Mutation Research, vol. 275, (1992) pp. 195-208.
Nishitani, Koji et al., "Lactate Dehydrogenase Isozyme Patterns of Normal Human Fibroblasts and their In Vitro-transformed Counterparts Obtained by Treatment with Co-60 Gamma-Rays, SV40 or 4-Nitroquinoline 1-oxide", Gann, 72, Apr. 1981, pp. 300-304.
Fleischmajer, Raul, M.D., et al., "Lactate Dehydrogenase Isozyme Patterns in Blister Fluids", The Journal of Investigative Dermatology, vol. 50, No. 5 (1968), pp. 405-408.
Godfredson et al., "1,6-dihydro-NAD as an Humidity Induced lactate dehydrogenase inhibitor in NADH Preparations", Carlsberg. Res. Comm., 43 (3), (1978), pp. 171-175.
Sheffield et al., "Synthesis of Some 4 Pyridyl Pyruvic Acids as Potential Inhibitors", J. Chem. Soc. Perkin Trans. I, No. 20, 1972, pp. 2506-2512.
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Co-pending application Serial No. 08/359,759.

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