Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2001-05-02
2002-04-30
Dees, Jose′ G. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S002600, C514S008100, C514S012200, C514S021800, C514S100000, C514S844000, C514S937000, C514S944000
Reexamination Certificate
active
06379684
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to cosmetic compositions containing cromolyn compounds. More particularly, there is provided cosmetic compositions containing anti-chymase, anti-tryptase and/or anti-elastase inhibitors, which improves or revitalizes atmosphere damaged skin including chapped lips, wind burn, sun burn and wrinkles resulting therefrom, as well as natural skin eruptions.
BACKGROUND OF THE INVENTION
Human type serine protease inhibitors such as cromolyn compounds have been proposed for use in cosmetic compositions. However, these proteins are expensive and cannot be utilized in many cosmetic preparations since they are subject to degradation by other ingredients and are temperature sensitive with limited shelf-lives.
Cromolyn sodium is commercially available in anti-asthma formulations for its property of preventing mast cell degranulation.
Household pets such as cats and dogs obtain rashes, develop itching as a result of soap, chemicals, insect bites, etc., which are commonly treated with over-the-counter medicaments since they are only minor irritations.
Hydrocortisone has been used with little effect. There is a need for an inexpensive and effective composition for treating pets for their minor irritations, which has a broad spectrum of effects so to be used on undiagnosed causes for the irritation.
SUMMARY OF THE INVENTION
The present invention provides a topical cosmetic composition for improving or revitalizing the texture of skin or as a prophylactic against skin irritations or degradations resulting from exposure to the sun. The composition is especially useful for treating skin damaged by the atmosphere such as sun damaged or wrinkled skin, chapped lips or skin, or to prevent skin eruptions.
The cromolyn compounds, which can be used in the present invention, include cromolyn, cromolyn sodium, disodium cromolyn, the lower alkyl esters and derivatives thereof.
The wound healing properties of cromolyn compounds are helpful in cosmetic preparations, which are intended to cover blemishes or skin eruption.
The compositions of the invention contain at least about 0.5 percent of the cromolyn compounds. The amount of cromolyn compounds, which generally can be used, is about one percent by weight, preferably, about 1 to 10% by weight of composition. Greater amounts can be utilized but are not required to achieve the desired results.
The compositions of the invention can be used in the form of a lotion, creme, gel or solution, depending on the use or treatment contemplated. The extract can be formulated into cosmetic compositions such as lipsticks, hand cremes, after sun compositions, and the like.
Cromolyn compounds possess anti-PAR-2 (protease-activated receptor-2) characteristics so that they affect the inflammatory cascade differently than alpha 1-antitrypsin, which is anti-IgE and anti-glycosylation factors (GEF). It is believed that anti-PAR-2 permits the cromolyn to be effective more quickly on blemishes and rashes, which may not involve mast cells or elevated IgE.
The cromolyn compounds can be used alone or with other skin treatment compounds such as aloe vera.
It is a general object of the invention to provide a cosmetic composition, which contains an effective amount of the cromolyn compound to improve the quality of the skin.
It is another object to provide a cosmetic composition for treating sensitive skins.
It is yet another object to provide a method and topical composition which helps revitalize environmentally damaged skin.
It is a still further object of the invention to provide a method for improving damaged skin as a result of ultra-violet radiation.
It is also an object of the invention to provide a composition having anti-PAR-2 characteristics.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention provides an improvement in cosmetic compositions by providing safe and natural chymase, tryptase and/or elastase inhibitors which are non-irritating to human or animal skin.
The favorable cosmetic activity of the cromolyn compounds is believed to be the results of the chymase, tryptase and elastase inhibition by the cromolyn compounds before or during inflammation. Also, the control of the elastase permits the laying down of new tissue without degradation resulting from the presence of excess elastase. After a solar peel or removal of the upper dermal layer mechanically or naturally, the new tissue layer which is layed down is more resilient and thereby reduces the wrinkles unless scarring or degradation occurs due to excess elastase. In aging skin, the cromolyn compounds appear to revitalize as well as soften the existing skin. The compositions with the cromolyn compounds have a prophylactic effect and reduce the incidence of skin eruptions or inflammations as a result of the action against serine proteases or mast cell involvement. The compositions are further useful for lightening the skin and to reduce the effect of hyperpigmentation.
The compositions according to the invention may be presented in all forms normally used for topical application, in particular in the form of aqueous, aqueous-alcoholic or, oily solutions, or dispersions of the lotion or serum type, or anhydrous or lipophilic gels, or emulsions of liquid or semi-solid consistency of the milk type, obtained by dispersing a fatty phase in an aqueous phase (O/VV) or vice versa (VV/O), or of suspensions or emulsions of soft, semi-solid consistency of the cream or gel type, or alternatively of microemulsions, of microcapsules, of microparticles or of vesicular dispersions of the ionic and/or nonionic type. These compositions are prepared according to standard methods.
The amounts of the different constituents of the compositions according to the invention are those traditionally used in the cosmetic field.
These compositions constitute, in particular, cleansing, protective, treatment or skin care creams for the face, hands, feet, major anatomical folds or the body (for example day creams, night creams, make-up removal creams, foundation creams, sun-protection creams), fluid foundations, make-up removal milks, protective or skin care body milks, after-sun milks, skin care lotions, gels or foams, such as cleansing or disinfecting lotions, bath compositions, deodorant compositions, aftershave gels or lotions, and compositions for treating certain skin disorders such as those mentioned above.
The sun can produce a series of lesions on the skin, which can be precancerous (e.g. seborrheic, keratoses or actinic keratoses) Treatment with cromolyn compounds reduces the risk of cellular proliferation when applied in a suitable composition after exposure to the sun or ultra-violet radiation.
The compositions according to the intention may also consist of solid preparations constituting cleansing bars or soaps.
The compositions may also be packaged in the form of an aerosol composition containing a propellant agent under pressure.
When the composition of the invention is an emulsion, the proportion of the fatty phase can range from 5% to 80% by weight, and preferably from 5% to 50% by weight, relative to the total weight of the composition. The oils, emulsifiers and coemulisifiers used in the composition in emulsion form are chosen from those traditionally used in the cosmetics. The emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight, and preferably 0.5 to 30% by weight or, better still, from 0.5 to 20% by weight relative to the total weight of the composition. The emulsion can, in addition, contain lipid vesicles.
When the compositions of the invention is an oily gel or solution, the fatty phase can represent more than 90% of the total weight of the composition.
In a known manner, the composition of the invention may also contain adjuvants which are customary in cosmetics, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, perfumes, fillers, screening agents, bactericides, odor absorbers and coloring matter. The amounts of these diff
Kronis K. Anne
Lezdey Darren
Lezdey John
Alphamed Pharaceutical Corp.
Lamm Marina
Lezdey John
LandOfFree
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