Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1996-08-12
1998-09-29
Mosley, Terressa
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
106205, 106208, 2523153, 351160H, 424492, 424496, 424500, 536 11, 536 41, 536115, 536123, 536124, A61K 916
Patent
active
058143416
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to cosmetic compositions and, in particular, to such compositions containing a glucan as an active ingredient.
In GB-A-2 050 825 there is described a skin cosmetic composition of the oil-in-water type, comprising an emulsifying agent, an oil and water, the emulsifying agent being composed of a) at least one specified glycyrrhizic compound and b) at least one water-soluble polysaccharide selected from pectin, karaya gum, locust bean gum and xanthan gum.
The polysaccharides used in GB-A-2 050 825 have certain disadvantages, namely that they contain acidic groups, rendering them sensitive to salt formation and/or variations in pH, as well as a lack of stability over an adequate temperature range.
In JP 030167109 there is described a cosmetic material containing a .beta.-1,3-glucan having a mean molecular weight greater than 10.10.sup.6. .beta.-1,3-glucans having a mean molecular weight greater than 10.10.sup.6, however, are of poor aspect, and their molecular weight cannot be determined using the conventional light scattering method.
It has now been found that certain glucans are useful as active ingredients and as excipients in cosmetic compositions, without the disadvantages associated with the polysaccharides used in GB-A-2 050 825 or with the .beta.-1,3-glucans of JP 030167109. Moreover, the glucans used in the present compositions, on drying, form flexible films which, although insoluble in water, swell readily therein. This ability to form films represents an added advantage for the use of these glucans in cosmetic formulations:
Accordingly, the present invention provides a cosmetic composition comprising: the total composition, of a .beta.-1,3-glucan having a mean molecular weight of 10.sup.5 to 10.10.sup.6, preferably 2 to 10.10.sup.6.
The cosmetic composition may constitute, e.g., a shampoo and/or hair conditioner composition, in which the glucan component B) may perform one or more of the following functions: shampoo/conditioner; shampoo/conditioner; shampoo/conditioner; and or UV absorbers in the shampoo/conditioner.
The cosmetic composition according to the present invention may also constitute a skin care composition, e.g., an emulsion or cream in which the glucan may perform one or more of the following functions: composition on the skin; skin, which film, while almost undetectable by touching, provides the skin with a silky feel; outermost layer of stratum corneum; care composition; and
The skin care composition may be formulated as an aqueous lotion, a water-in-oil or an oil-in-water emulsion, an oil or oil-alcohol lotion, a vesicular dispersion of anionic or nonionic amphiphilic lipids, an aqueous, aqueous-alcohol, alcohol or oil-alcohol gel, a solid stick or an aerosol formulation.
When formulated as a water-in-oil or an oil-in-water emulsion, the cosmetically acceptable carrier A) preferably comprises 5 to 50% of an oil phase; and 47 to 94.95% of water, each based on the total weight of the composition.
The oil phase may comprise any oil, or mixture thereof,. which is known to be suitable for use in cosmetic compositions.
Examples of such oils include aliphatic hydrocarbons such as liquid paraffin, squalane, vaseline and ceresin; vegetable oils such as orive oil, almond oil, sesame oil, avocado oil, castor oil, cacao butter and palm oil; animal oils such shark liver oil, cod liver oil, whale oil, beef tallow and butter fat; waxes including bees wax, carnauba wax, spermaceti and lanolin; fatty acids such as lauric acid, myristic acid, , palmitic acid, stearic acid, oleic acid and behenic acid; aliphatic alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol and oleyl alcohol; and aliphatic esters such as isopropyl-, isocetyl- or octadecyl myristate, butyl stearate, hexyl laurate, diisopropyl adipate or diisopropyl sebacate.
Preferred mono- or polyols, for use in an oil-alcohol lotion, or a an oil-alcohol or alcohol gel, include ethanol, isopropanol, propylene glycol, hexylene glycol, glycerine and sorbitol.
When the .beta.-1,3-glucan is used as a co-emu
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Fankhauser Peter
Maier Thomas
Ciba Specialty Chemicals Corporation
Mansfield Kevin T.
Mosley Terressa
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