Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1997-06-16
2002-02-19
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S195110, C424S070100, C424S070170
Reexamination Certificate
active
06348200
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to cosmetic compositions which can enhance the water-retaining ability of the horny layer and have excellent effects in improving skin roughness and preventing the formation of wrinkles.
2. Discussion of the Background
The water content of the horny layer has heretofore been known to be critical for imparting moisture to the skin to maintain skin smoothness and softness. The retention of water in the horny layer is said to rely upon a water-soluble component contained in the horny layer, namely, a free amino acid, organic acid, urea or inorganic ion.
In the above circumstances, these materials have been incorporated either singly or in combination in cosmetics and the like with a view toward improving or preventing skin roughness.
Besides, many humectants having a high affinity for water have also been developed and have been used for improving the skin roughness.
However, these humectants remain on the skin surface when they are applied to the skin, so that they serve to supply water to the horny layer. Moreover, their effects are temporary and they are not such that can fundamentally improve the water-retaining ability of the horny layer itself and can prevent or cure skin roughness substantially.
Therefore, the present applicant previously proposed, as an external skin care composition having the effect of fundamentally improving the water-retaining ability of the horny layer, an external skin care composition [Japanese Patent Publication No. 42934/1989 (Japanese Patent Application Laid-Open No. 228048/1987)] comprising an amide derivative represented by the following formula (a):
wherein R
1b
is a linear or branched and saturated or unsaturated hydrocarbon group having 10-26 carbon atoms, and R
2b
is a linear or branched and saturated or unsaturated hydrocarbon group having 9-25 carbon atoms.
Further, the present applicant proposed external skin care compositions having the same effects as described above in Japanese Patent Application Laid-Open Nos. 216812/1988, 218609/1988, 222107/1988, 227513/1988, 29347/1989, and 31752/1989, etc.
However, the amide derivatives used in these external skin care compositions bring about the excellent effects as described above, but have such properties as high melting point, high crystallinity and low solubility in a base, and so they still involve problems to be solved from the viewpoint of penetration into the skin, and the like when incorporated into cosmetics. There has thus remained a demand for development of a cosmetic composition having excellent effects in improving skin roughness.
SUMMARY OF THE INVENTION
It is therefore an object of the present invention to provide novel cosmetic compositions which have the effect of fundamentally improving (maintaining or enhancing) the water-retaining ability of the horny layer.
It is another object of the present invention to provide novel cosmetic compositions which can prevent and cure skin roughness or inflammation, and moreover can prevent dermal aging such as the formation of wrinkles to enhance the protective and maintenance performance of the skin.
These and other objects, which will become apparent from the following detailed description, have been achieved by the inventors' discovery that cosmetic compositions comprising at least one compound selected from novel amide derivatives represented by the general formulae (1) to (4), which will be described subsequently, and at least one ingredient selected from polyhydric alcohols, vegetable extracts and organic acids or salts thereof can achieve the above object, thus leading to completion of the present invention.
According to the present invention, there is thus provided a cosmetic composition comprising the following components (A) and (B):
(A) at least one compound selected from the amide derivatives represented by the following general formulae (1), (2), (3) and (4):
wherein R
1
and R
2
are identical to or different from each other and are, independently, a hydrocarbon group having 1 to 40 carbon atoms, which may be hydroxylated, R
3
is a linear or branched alkylene group having 1 to 6 carbon atoms, or a single bond, and R
4
is a hydrogen atom, a linear or branched alkoxyl group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, with the proviso that when R
3
is a single bond, R
4
is a hydrogen atom;
wherein R
1a
is a hydrocarbon group having 4 to 40 carbon atoms, which may be hydroxylated, R
3a
is a linear or branched alkylene group having 3 to 6 carbon atoms, and R
4a
is a linear or branched alkoxyl group having 1 to 12 carbon atoms,
wherein R
1
and R
2
are identical to or different from each other and are, independently, a hydrocarbon group having 1 to 40 carbon atoms, which may be hydroxylated, R
3a
is a linear or branched alkylene group having 3 to 6 carbon atoms, and R
4a
is a linear or branched alkoxyl group having 1 to 12 carbon atoms;
wherein R
1
and R
2
are identical to or different from each other and are, independently, a hydrocarbon group having 1 to 40 carbon atoms, which may be hydroxylated, R
3
is a linear or branched alkylene group having 1 to 6 carbon atoms, or a single bond, and R
4b
is a hydrogen atom, a linear or branched alkoxyl group having 1 to 12 carbon atoms, or a 2,3-epoxypropyloxy group, with the proviso that when R
3
is a single bond, R
4b
is a hydrogen atom; and
(B) at least one component selected from the group consisting of (B-1) polyhydric alcohols, (B-2) vegetable extracts and (B-3) organic acids or salts thereof.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
In the amide derivative (1) represented by the general formula (1) of the component (A) useful in the practice of the present invention, R
1
and R
2
are identical to or different from each other and are, independently, a linear or branched and saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, which may be hydroxylated. Examples of R
1
and R
2
include methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, heneicosyl, docosyl, nonacosyl, triacontyl, isostearyl, isoheptadecyl, 2-ethylhexyl, 1-ethylheptyl, 8-heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 2-heptylundecyl, 9-octadecenyl, 1-hydroxynonyl, 1-hydroxypentadecyl, 2-hydroxypentadecyl, 15-hydroxypentadecyl, 11-hydroxyheptadecyl, and 11-hydroxy-8-heptadecenyl.
As R
1
, linear or branched alkyl or alkenyl groups having 8 to 26 carbon atoms are preferred. Examples thereof include octyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, triacontyl, isostearyl, 2-ethylhexyl, 2-heptylundecyl, and 9-octadecenyl. Linear or branched alkyl groups having 12 to 22 carbon atoms are particularly preferred hydrocarbon groups as R
1
. Examples thereof include dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, and methyl-branched isostearyl groups.
As R
2
, linear or branched alkyl or alkenyl groups having 9 to 25 carbon atoms are preferred. Examples thereof include nonyl, undecyl, tridecyl, tetradecyl, pentadecyl, heptadecyl, heneicosyl, nonacosyl, isoheptadecyl, 1-ethylheptyl, 8-heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 1-hydroxynonyl, 1-hydroxypentadecyl, 2-hydroxypentadecyl, 15-hydroxypentadecyl, 11-hydroxyheptadecyl, and 11-hydroxy-8-heptadecenyl. Linear or branched alkyl groups having 11 to 21 carbon atoms are particularly preferred hydrocarbon groups as R
2
. Examples thereof include undecyl, tridecyl, tetradecyl, pentadecyl, heptadecyl, heneicosyl, and methyl-branched isoheptadecyl groups.
R
3
is a linear or branched alkylene group having 1 to 6 carbon atoms, or a single bond. Examples of the alkylene group include methylene, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, 1-methylethylene, 1-methyltrimethylene, 2-methyltrimethylene, 1,1-dimethylethylene, 1-ethylethylene, 1-methyltetramethylene, and 2-ethyltrimethylene. As R
3
, linear alkylene groups having 1 to 6 carbon atom
Fukuda Masataka
Morita Takeshi
Nakajima Atsushi
Sadahiro Tomoko
Uesaka Toshio
Di Nola-Baron Liliana
Kao Corporation
Oblon, Spviak, McClelland, Maier & Neustadt, P.C.
Page Thurman K.
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