Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1996-10-10
1999-05-11
Duffy, Patricia A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
514553, 514558, 514724, 514844, 514937, 514938, 514939, 514943, 554 1, 554227, C07C69/30
Patent
active
059025905
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to cosmetic and/or pharmaceutical formulations with increased viscosity and improved stability in storage which are distinguished by a content of selected esters of oligoglycerols with fatty acids as emulsifiers.
2. Discussion of Related Art
Emulsifiers are required for the permanent homogeneous mixing of substances which would otherwise be immiscible with one another. Esters of fatty acids with polyhydric alcohols, for example pentaerythritol, dipentaerythritol, or self-condensation products of glycerol, so-called technical oligoglycerol mixtures, are often used for this purpose in cosmetic and pharmaceutical formulations, for example for the production of cremes and notions. A review of this subject by G. Schuster and H. Pospischil was published in Arztl. Kosmetol., 11, 30-37 (1981).
The use of polyglycerol esters as o/w emulsifiers for cosmetic formulations is described, for example, in J. Soc. Cosmet. Chem. 28, 733-740 (1977) and in Fette, Seifen, Anstrichmittel 88, 101-106 (1986).
In addition, the use of selected polyglycerol fatty acid esters as cosmetic emulsifiers is claimed in DE-A1 40 05 819 and in DE-A1 40 23 593 (BASF). However, in cases where the esters based on unsaturated or saturated fatty acids mentioned in these documents are used, it has been found that the resulting emulsions are not always sufficiently stable in storage and/or are low in viscosity, i.e. have a viscosity which is not sufficiently high, so that problem-free dosing is difficult.
Accordingly, the problem addressed by the present invention was to provide new emulsifiers based on technical oligoglycerol mixtures and fatty acids which would not have any of the disadvantages mentioned above.
DESCRIPTION OF THE INVENTION
The present invention relates to cosmetic and/or pharmaceutical formulations which are characterized in that they contain statistical monoesters of technical triglycerol with saturated C.sub.16/18 fatty acids as emulsifiers, the monoester content being from 30 to 50% by weight.
It has surprisingly been found that the degree of self-condensation of the oligoglycerols in conjunction with the nature of the fatty acid and the percentage content of monoesters has a critical bearing on the properties of the resulting emulsifiers. The invention includes in particular the observation that the establishment of a percentage monoester content of 30 to 50% in the emulsifiers according to the invention leads to a significant improvement in storability and viscosity compared with otherwise known products of the prior art.
Esters of technical triglycerol with fatty acids are known substances which may be obtained by the relevant methods of preparative organic chemistry. Thus, according to the above-cited documents DE-A1 40 05 819 and DE-A1 40 23 593, technical triglycerol is esterified with fatty acids in the presence of hypophosphorous acid at 180.degree. C. and the water of reaction is continuously distilled off from the equilibrium.
In statistical terms, the triglycerol fatty acid esters are monoesters or, more accurately, esters of--on average--1 mole of technical triglycerol with 1 mole of fatty acid. This can produce the following typical distribution:
In addition, the emulsifiers may be derived from technical triglycerol with the following composition:
Triglycerol fatty acid esters which show particularly advantageous properties in the context of the present invention are distinguished by at least one of the following two properties: weight; weight, based on the oligoglycerol content.
In addition, the emulsifiers may be derived from saturated fatty acids containing 16 to 18 carbon atoms, i.e. for example from stearic acid, tallow fatty acid and, more particularly, palmitic acid. According to the invention, particularly preferred emulsifiers are palmitic acid esters which have a monoester content of 35 to 50% by weight and a triglycerol content of 35 to 55% by weight, based on their oligoglycerol content.
The emulsifiers may be present in t
REFERENCES:
patent: 3936391 (1976-02-01), Gabby et al.
patent: 5147644 (1992-09-01), Oppenlaender et al.
patent: 5424469 (1995-06-01), Jakobson et al.
Arztl. Kosmetol, 11 (1981) pp. 101-106.
J.Soc.Cosmet.Chem 28 (1977) pp. 733-740.
Fette, Seifen, Anstrichmittel 88 (1986) pp. 101-106.
Kosmetische Farbemittel of the Farbstoffkommission der Deutschen Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984 pp. 81-106.
Lehninger, A., "Principles of Biochemistry" Worth, New York (1982), pp. 56-57.
Ansmann Achim
Bunte Reinhard
Hees Udo
Kawa Rolf
Thomas Heike
Duffy Patricia A.
Grandmaison Real J.
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Szoke Ernest G.
LandOfFree
Cosmetic and/or pharmaceutical formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cosmetic and/or pharmaceutical formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cosmetic and/or pharmaceutical formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-244476