Cosmetic and/or pharmaceutical composition containing a dispersi

Details Cosmetic and/or pharmaceutical composition containing a dispersi Cosmetic and/or pharmaceutical composition containing a dispersi

1995-02-08

1997-05-06

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, 4284022, 514944, A61K 9127

Patent

active

056268688

ABSTRACT:
A composition comprises in an aqueous dispersion phase, a dispersion of lipid vesicles that encapsulate an aqueous phase. The lipid vesicles are a lipid phase containing an ionic amphiphilic lipid or a nonionic amphiphilic lipid, or a mixture thereof, together with a compound having the formula ##STR1## wherein (a) W represents --CH.sub.2 OH, --COOM or --(CH.sub.2).sub.2 --COOM, wherein M represents H, alkali metal or alkaline earth metal and X, Y, Z and V, each independently, represent hydrogen or hydroxyl, with the proviso that when W represents --CH.sub.2 OH at least one of X, Y, Z or V represents hydroxyl, or (b) W represents --CH.sub.3 and X, Y, Z and V represent H or OH combined as shown in each line of the table below:

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patent: 5192544 (1993-03-01), Grollier
patent: 5234767 (1993-08-01), Wallach
patent: 5268180 (1993-12-01), Morancais
Yue et al, "Deuterium NMR study of the magnetic orientation.", Biochem. Biophys. Acta, Lipids and Lipid Metabolism, vol. 1047, No. 1, 1990, pp. 1-10.
Cushley et al, "Structure and stability of vitamin E-lecithin and phytanic acid-lecithin bilayers studied by 13C and 31P nuclear magnetic resonance", Can. J. Chem. vol. 55, No. 2, 1977, pp. 220-226.
Roding, "Natipide II: New easy liposome system", Seifen--Ole--Fette--Wachse, 116, No. 14, 1990.

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