Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1996-01-03
1999-01-19
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
424400, 424401, 424489, 424490, 514844, 514847, 514848, 514873, A61K 31045
Patent
active
058614400
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to cosmetic and medicinal topical care formulations, in particular those which, when applied to the skin or mucous membranes, have a moisturizing and cooling effect.
Such compositions are known per se. Described in the literature as cooling agents are, for example, ionic compounds, in particular ammonium salts. Isopropanol gels with an addition of camphor and menthol are also widely used as cooling formulations.
Essential oils, mostly camphor and menthol, but also their derivatives, for example menthyl lactate or menthyl 3-hydroxybutyrate, are generally frequently incorporated into cooling compositions.
Menthol and camphor and their derivatives, but also other essential oils, reduce the stimulus threshold of the neuronal thermoreceptors, causing a cold sensation. However, frequently they favour the blood flow at the same time and this, on the contrary, causes a warm sensation.
In any case, the use of these substances causes problems, in particular on irritated skin. Moreover, the water solubility of many of these compounds is poor. As a consequence, their use is limited to a few cosmetics and products for dermal use.
It was therefore an object of the present invention to provide cosmetic and medicinal care formulations which do not have the shortcomings of the prior art, in particular those which, when applied to the skin or mucous membranes, have a moisturizing and/or cooling effect.
This object is achieved according to the invention by using cosmetically or pharmacologically acceptable substances having a positive solution enthalpy in cosmetic or medicinal topical formulations, characterized in that the substance, or the substances, are present in the formulations in an essentially anhydrous medium and/or are protected from an aqueous medium by means of a physical barrier.
As a particularly advantageous embodiment of the present invention, the object is achieved by cosmetic and dermatological compositions containing one or more sugar alcohols of the general formula ##STR1## where n=3, 4 and 5 and formulations in an essentially anhydrous medium and/or are protected from an aqueous medium by means of a physical barrier.
It is known that some sugar alcohols have a positive solution enthalpy when dissolved in water under standard conditions, i.e. the temperature of the solution drops during the dissolution process. From amongst the sugar alcohols, xylitol has the highest positive solution enthalpy. Xylitol is the preferred sugar alcohol used according to the invention.
Xylitol, as represented by the Fischer projection, has the structural formula ##STR2##
It has the meso configuration and is therefore not optically active.
Xylitol (xylo-pentanepentol) can be obtained industrially by hydrogenating xylose and is employed, for example, as the sugar substitute for diabetics. Occasionally, it is used as a humectant in cosmetic formulations.
However, it was unknown to utilize the positive solution enthalpy of cosmetically or pharmacologically acceptable substances in general or of the sugar alcohols according to the invention in particular for use in cosmetic or medicinal topical formulations which have a cooling effect.
Other substances which are active according to the invention are uronic acids of the general formula ##STR3## where n=3, 4 and 5 (or their cyclic forms) and their salts as long as these uronic acids, or uronic acid salts, are distinguished by a positive solution enthalpy and by cosmetic or pharmacological acceptability.
An advantageous uronic acid salt according to the invention is sodium mannuronate, which is distinguished by the following structure: ##STR4##
It was particularly surprising that the cooling effect of xylitol can be increased even more according to the invention in combination with substances selected from the group comprising mannitol, sorbitol, propylene glycol, glycerol, urea, 2-pyrrolidone-5-carboxylic acid and its sodium salt, and also sodium mannuronate. Relative to the cooling effect of the individual substances, the increase in the cooling effec
REFERENCES:
patent: 4427010 (1984-01-01), Marx
Gohla Sven
Heinze Friedrich
Nielsen Jens
Thamssen Carl
Beiersdorf Aktiengesellschaft
Dodson Shelley A.
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