Coryneform bacteria with altered glucokinase activity in the...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S320100, C435S252300, C435S254110, C435S254200, C435S257100, C536S023100

Reexamination Certificate

active

10498889

ABSTRACT:
The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.

REFERENCES:
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patent: 2002/0040129 (2002-04-01), Möckel et al.
patent: 2003/0022320 (2003-01-01), Möckel et al.
patent: 1 106 694 (2001-06-01), None
patent: 1 108 790 (2001-06-01), None
Ngo et al. in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Bischoff, J., Domrachev, M., Federhen, S., Hotton, C., Leipe, D., Soussov, V., Sternberg, R., and Turner, S., NCBI Taxonomy Browser[online]: Retrieved from the internet using “Coryneform bacteria” at <URL: http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/xxxtax.cgi>.
Pompejus et al.; “Corynebacterium glutamicumSMP Protein Sequence SEQ ID No: 24” DATABASE GSP ′online! EBI, Hinxton, Camdridgeshire, UK; Apr. 30, 2001.
Nakagawa et al.: “C glutamicumProtein Fragment SEQ ID No: 6984.” DATABASE GSP ′online! EBI, Hinxton, Cambridgeshire, UK; Sep. 26, 2001.
Lee J.K. et al.: “Characterization of GLK, A Gene Coding for Glucose Kinase ofCorynebacterium glutamicium”; Abstracts of the General Meeting of the American Society for Microbiology, American Society for Microbiology, Washington, D.C.; vol. 99, Jun. 3, 1999; p. 369.
Park Sun-Yang et al.; “Characterization of glk, a gene coding for Glucose Kinase ofCorynebacterium glutamicum”; FEMS Microbiology Letters, Amsterdam, NL,; vol. 188, No. 2, Jul. 15, 2000.

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