Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-03-22
2000-03-21
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4241661, 4242451, 530325, 530326, 530327, 530350, 5303871, 5303879, 5303882, 5303884, 530402, 530825, G01N 33569, C07K 1434, C07K 700, A61K 3905
Patent
active
060401486
ABSTRACT:
The present invention relates to a purified stress protein of 86 Kd and fragments thereof isolated from the genus Corynebacterium. Particular fragments include those with apparent molecular weights of 50 Kd and 52 Kd. The stress protein has been found to be an immunodominant conserved antigen. Patients with Corynebacterium jeikeium septicemia or endocarditis have antibody to the 52 Kd breakdown product. The protein cross-reacts with a peptide antigen KVIRKNIVKKMIE (see SEQ ID No. 1) using a mouse monoclonal antibody against the peptide. The stress protein is useful for improved diagnosis, monitoring and treatment of Corynebacterium infections and diseases.
REFERENCES:
patent: 4879213 (1989-11-01), Fox et al.
patent: 5288639 (1994-02-01), Burnie et al.
Clark et al. Characterization of the antibody response in Coryne-bacterium jeikeium sp. Epidemol. Intect.; 105(2) 229-236 1990- (see abstract).
Young R.A. Stress Proteins as Immune Targets in Bacterial and Parasitic Infections. pp. 123-130 See In Immune Recognition and Evasion. Van der Pleog et al Editor 1990.
Jackman et al. Characterization of Corynebacterium Group JK by Whole-Cell Protein Patterns, J. Gen. Microbiol 132:1911-15 1986.
Jackman et al. Classification of Corynebacterium Associated with Endocarditis (Group JK) as Corneybacterium jeikeium sp. Nov. System Applied. Microbiol. 9:83-90 1987.
Christman et al. Positive Control of a Regulon for Defenses against Oxidative Stress and Some Heat Shock Proteins in S. typhimurium Cell 41:753-62 1985.
Morgan et al. Hydrogen Peroxide -inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins PNAS 83(21): 8059-63 1986.
Tortora et al. Microbiology an Introduction. 1989 see p. 85 published by Benjamin/Cummings Publishing Company, Inc.
Lazar et al. Molecular and Cellular Biology 8(3):1247-52, Mar. 1988.
Burgess et al. The Journal of Cell Biology 111:2129-38, Nov. 1990.
Plotkin (ed), "Vaccines", published by W.B. Saunders Company (Philadelphia), see p. 571 of Chapter 29, 1988.
Stein et al., Science 261:1004-1021, Aug. 1993.
Tizord,I (Ed.) "An Introduction to Veterinary Immunology", by published W.B. Saunders Co. (Phil) in 1982, See p. 32.
Harlow and Lane, Antibodies, A Laboratory Manual, 1988, pp. 553-612.
R. Matthews et al: "Cloning of a DNA sequence encoding a major fragment of the 47 kilodalton stress proteiner stress protein homoloque of Candida albicans" Chemical Abstracts, vol. 111, No. 13, Sep. 1989, p. 199.
H. Yamaguchi et al: "Yarsinia enterocolitica immunodominant 60 KDa antigen, common to a broad range of bacteria is a heat-shock protein", Biological Abstracts, vol. 90, 1990.
C.K. Stover et al: "Molecular cloning and sequence analysis of the STA 58 . . . ", Infection and Immunity, vol. 58, No. 5, May 1990, pp. 1360-1368, see the whole article.
J.L. Brissette et al: "Phage shock protein, a stress protein of Escherichia coli", Proceedings of the National Acadamy of Sciences, vol. 87, No. 3, Feb. 1990, Biochemistry, pp. 862-866, see the whole article.
Caputa Anthony C.
The Victoria University of Manchester
LandOfFree
Corynebacterial stress proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Corynebacterial stress proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Corynebacterial stress proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-729519