Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-05-21
1999-03-30
Feisee, Lila
Chemistry: molecular biology and microbiology
Vector, per se
536 231, 536 235, 530350, 530300, 435 691, 4352523, 43525411, 435325, C07K 1472, C12N 1511, C12N 510, C12N 1509
Patent
active
058888110
ABSTRACT:
A novel human corticotropin releasing hormone (CRH) receptor which is a splice variant of the human CRH.sub.2 receptor subfamily and is designated human CRHR2.gamma.. Fragments of CRHR2.gamma.. Nucleic acid molecules which encode CRHR2.gamma. and fragments, expression vectors comprising the nucleic acid molecules, and host cells containing the expression vectors. Antibodies and antibody fragments capable of binding the novel receptor. Nucleic acid molecules capable of hybridizing with the above nucleic acid molecules. Use of the novel receptor and receptor fragments, antibodies and antibody fragments in testing compounds for CRH antagonist activity and in treating diseases.
REFERENCES:
Liaw et al., Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid, Encodrinology, 137(1): 72-77, Jan. 1996.
Perrin et al., Identification of a secon corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart, Proc. Natl. Acad. Sci, USA, 92: 2969-2973, Mar. 1995.
Lerner, RA, Antibodies of predetermined specificity in biology and medicine, Adv. Immunol., 36: 1-43, 1984.
Stenzel et al., Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart, Mol. Endocrinol., 9: 637-645, 1995.
Chen Ai-Ru
Kostich Walter Alan
Largent Brian Lee
Sperle Karen Marie
DuPont Pharmaceuticals Company
Feisee Lila
Kaufman Claire M.
Kerr Don M.
Vance David H.
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